Predoctoral Program in Biophysics

项目描述（申请人提供）：拟设立生物物理学研究生培训项目。将继续进行化学系和分子生物物理及生物化学系（MB&B）生物物理组之间的联系培训计划。结构生物学，包括晶体学、核磁共振和计算方法，构成了我们生物物理学项目的核心；在21名培训教员中，三分之二以上的教员积极采用其中一种或多种方法。其他研究领域包括，例如，大分子稳定性和动力学，膜生物物理学，细菌运动，能量转导过程，溶液中自由能变化的计算和生物环境中的动态过程，以及体内代谢的核磁共振研究。用于培训的研究实验室包括位于斯特林和克莱恩化学实验室、新巴斯实验室、吉布斯实验室、斯特林医学大厅和医学院磁共振中心的45,000净平方英尺的空间。斯特林、克莱恩、巴斯和吉布斯实验室现在形成了一套相互连接的建筑，将生物物理学的许多研究小组聚集在一个大的楼层里。可供学员使用的主要设施包括耶鲁大学结构生物学中心的晶体学、计算和图形资源、W. M.凯克基金会磁共振中心、化学仪器中心、巴斯实验室核磁共振设施以及医学院核磁共振成像和代谢研究的核磁共振中心。该计划将支持12名博士预科学员，所有人都至少有学士学位经验。在第一年，受训者被提供课程工作和实验室轮转，随后几年进行密集的研究工作和一些专门的课程工作。所有学生都必须教一年。强调了在生物物理学中增加少数族裔代表的项目。所有受训者都必须接受与研究有关的伦理问题的教育。

DESCRIPTION (provided by applicant): A program for support of graduate student trainees in Biophysics is proposed. The Training Program that links the biophysics groups in the Departments of Chemistry and Molecular Biophysics and Biochemistry (MB&B) will be continued. Structural biology, including crystallographic, NMR, and computational methods, constitutes the core of our biophysics program; more than two thirds of the 21 training faculty are active in one or more of those methods. Additional areas of study include, for example, macromolecular stability and dynamics, membrane biophysics, bacterial motility, energy transduction processes, computation of free energy changes in solution and dynamical processes in biological environments, and NMR studies of metabolism in vivo. Research laboratories for training include about 45,000 net square feet of space housed in Sterling and Kline Chemistry Laboratories, the new Bass Laboratory, Gibbs Laboratory, Sterling Hall of Medicine, and the Medical School Magnetic Resonance Center. Sterling, Kline, Bass and Gibbs Laboratories now form a set of inter-connected buildings, serving to bring together in a large floor plate many of the research groups in biophysics. Major facilities available for trainee use include the crystallographic, computational, and graphics resources of the Yale Center for Structural Biology, the W. M. Keck Foundation Center for Magnetic Resonance, the Chemical Instrumentation Center, the Bass Laboratory NMR facility, and the Magnetic Resonance Center for NMR imaging and metabolic studies at the Medical School. The proposed program will support 12 pre-doctoral trainees, all admitted with at least Bachelor's degree experience. Trainees are provided course work and laboratory rotations in the first year, followed by intensive research effort and some specialized course work in subsequent years. All students are required to teach for one year. Programs for increasing the representation of minorities in Biophysics are emphasized. Education in ethical issues related to research is required of all trainees.