CIRCULATORY CONTROL DURING EXERCISE: EFFECT OF DISEASE

描述(申请人摘要)：患者运动能力降低 心脏病和高血压限制了其治疗价值 处方药。这项建议的长期目标是了解循环系统 肌内躯体感觉输入介导的运动控制 慢性病。第一个目标是开发一种可重复性的练习 容易诱发心血管疾病的模型。去大脑的大鼠 将使用的制剂和机械的效果和 新陈代谢敏感的后肢传入活动对循环控制将 被调查。第二个目标是描述 心力衰竭发展后运动中的心血管控制。 采用冠状动脉结扎法建立大鼠心肌梗死模型。 心率、血压和肾交感神经活动的变化 将测量对静态肌肉收缩和被动肌肉的反应 去脑后伸展。第三个目标是确定以下方面的变化 高血压患者运动中循环调节方法的研究 如上所示。一种自发性高血压的基因工程菌株 将大鼠的反应与血压正常的对照组进行比较 老鼠。这些实验的结果不仅描述了一种新的动物 肌内神经控制心血管的研究准备 机制，但将导致对循环调节的更好理解 运动后表现为临床病理。

DESCRIPTION (Applicant's abstract):Exercise capacity is reduced in patients with heart disease and hypertension limiting the therapeutic value of its prescription. The long-term goal of this proposal is to understand circulatory control during exercise mediated by intramuscular somatosensory input in chronic disease. The first objective is to develop a reproducible exercise model in which cardiovascular disease is readily induced. A decerebrate rat preparation will be used and the effect of mechanically and metabolically-sensitive hindlimb afferent activity on circulatory control will be investigated. The second objective is to characterize alterations in cardiovascular control during exercise after the development of heart failure. Myocardial infarction will be induced in rats via coronary artery ligation. Changes in heart rate, blood pressure, and renal sympathetic nerve activity will be measured in response to static muscle contraction and passive muscle stretch after decerebration. The third objective is to identify changes in circulatory regulation during exercise in hypertension using the methods presented above. A genetically engineered strain of spontaneously hypertensive rats will be employed and responses compared to a control group of normotensive rats. Results from these experiments will not only describe a novel animal preparation for the study of cardiovascular control by intramuscular neural mechanisms but will lead to an improved understanding of circulatory regulation during exercise after the manifestation of clinical pathologies.