Optical Measurement of Choroid to Photoreceptor Distance

描述(申请人提供)：尽管自动验光仪的平均精度非常好，但它们仍然不能可靠地用于开眼镜处方，因为大约20%的患者将通过主观屈光度至少0.5度的不同来测量。此外，不同测量方法的患者在许多不同制造商生产的自动验光器上也有相同的误差。这表明，这两只眼睛在结构上存在一些差异。我们假设，显著的结构性差异是这些患者的光感受器与脉络膜血供之间的间距与普通人群不同。我们提出了一种测量光感受器到脉络膜间距的方法，以及使用该参数来改进这些患者计算的球面等效功率的方法。还提供了检验斯泰尔斯·克劳福德效应导致自动屈光与主观屈光不同的假设的方法。这项研究的预期好处包括改善和更早地检测各种视网膜病变，对糖尿病患者和其他人的潜在好处。医疗实践预计将受益于自动屈光技术的进步。

DESCRIPTION (provided by applicant): Although the average accuracy of autorefractors is very good, they still cannot be reliably used to write eyeglass prescriptions because about 20 percent of patients will be measured differently by subjective refraction by at least 0.5 diopters. Further, the patients that are measured differently have the same error on autorefractors made by many different manufacturers. This indicates that there is some structural difference in those eyes. We hypothesize that the significant structural difference is that the spacing between the photoreceptors to the choroid blood supply is different in those patients relative to the general population. We propose a method to measure the photoreceptor to choroid spacing and a method to use that parameter to improve the calculated spherical equivalent power on those patients. Means are also provided to test the hypothesis that the Stiles Crawford effect is responsible for the difference in autorefractions versus subjective refractions. Expected benefits of this research include improved and earlier detection of various retinal pathologies, potential benefits for diabetic patients and others. Medical practice is anticipated to benefit through advancements in automated refraction techniques.