Laser-Engineered Net Shape Ti/HA Composite Implants
Laser-Engineered Net Shape Ti/HA Composite Implants
批准号:
6443481
负责人:
Harold Alexander
金额:
$10.0万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-09-30 至 2004-03-31
中文摘要
描述:牙科植入物在当今世界各地普遍使用。
世界上治疗单颗牙齿脱落以及支持假牙的技术。组织
对牙种植体的反应与成分、表面
化学,以及植入材料的表面微观几何形状。生物活性
钛合金的性能将通过添加羟基磷灰石(HA)来改善
采用激光工程净成形(透镜)技术的粉末。CP钛
6Al-4V-Ti合金具有良好的生物相容性,但生物活性较低
对种植体表面的可变骨反应。据信,一种钙
丰富的表面加强了血小板的激活,并改善了纤维蛋白与
种植体表面。激光微槽表面改性和化学改性
通过镜片的改造应该会导致更快的骨骼生长和
贴合到种植体表面。镜头过程提供了一个机会
制造一种独特的HA浸渍钛合金牙科植入物,成本和
类似于当前的制造模式,结合了最佳表面
微观几何、机械设计、基础材料组成和表面
化学反应。这样的植入物可以在拔牙时植入和加载
拔牙为患者提供一颗经济实惠的新牙
或两次坐诊,而不是通常的3到6个月。
英文摘要
DESCRIPTION: Endosseous Dental implants are in common use today throughout the
world to treat single tooth loss and well as to support dentures. Tissue
response to a Dental implant correlates with the composition, surface
chemistry, and surface microgeometry of the implant material. The bioactivity
of titanium alloy is to be improved through the addition of hydroxyapatite (HA)
powder utilizing Laser Engineered Net Shaping (LENS) technology. CP titanium
and 6Al-4V-Ti alloy have good biocompatibility but low bioactivity resulting in
variable bone response to the implant surface. It is believed that a calcium
rich surface potentiates platelet activation and improves fibrin binding to the
implant surface. Surface modification through laser microgrooving and chemistry
modification through LENS should result is more rapid bone growth and
apposition up to the implant surface. The LENS process offers the opportunity
to manufacture a unique HA impregnated Ti alloy Dental implant with a cost and
ease similar to current manufacturing modalities incorporating optimum surface
microgeometry, mechanical design, base material composition and surface
chemistry. Such an implant could be implanted and loaded at the time of tooth
extraction providing the patient with a cost effective new tooth after just one
or two sittings, instead of the usual 3 to 6 months.
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Calcium Sulfate Based Bioactive Bone Graft
-
批准号:7394870
-
项目类别:
-
资助金额:$38.29万
-
财政年份:2004
-
负责人:Harold Alexander
-
依托单位:
Multiphasic Calcium Sulfate Bone Repair Material
-
批准号:6832895
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2004
-
负责人:Harold Alexander
-
依托单位:
Calcium Sulfate Based Bioactive Bone Graft
-
批准号:7688597
-
项目类别:
-
资助金额:$36.57万
-
财政年份:2004
-
负责人:Harold Alexander
-
依托单位:
Calcium Sulfate Based Bioactive Bone Graft
-
批准号:7830703
-
项目类别:
-
资助金额:$19.23万
-
财政年份:2004
-
负责人:Harold Alexander
-
依托单位:
A Mechanical/Neural Limb Prosthetic Interface
-
批准号:6620218
-
项目类别:
-
资助金额:$25.17万
-
财政年份:1995
-
负责人:Harold Alexander
-
依托单位:
A Mechanical/Neural Limb Prosthetic Interface
-
批准号:6405234
-
项目类别:
-
资助金额:$25.34万
-
财政年份:1995
-
负责人:Harold Alexander
-
依托单位: