Calcium Sulfate Based Bioactive Bone Graft

硫酸钙基生物活性骨移植物

基本信息

  • 批准号:
    7394870
  • 负责人:
  • 金额:
    $ 38.29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-09-08 至 2010-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The aim of this research is to develop an improved, synthetic bone graft material for use in dentistry. The loss of teeth is often accompanied by the loss of jaw bone. Restoring this lost bone is often a prerequisite for the installation of dental implants and the maintenance of normal facial features. Calcium sulfate works quite well as a bone regeneration material. It serves not only as a defect filler, but is also biocompatible, conducts new bone growth and encourages the growth of new blood vessels. However, its fast degradation is its major shortcoming, restricting its use in bone grafting applications. Based upon a successful phase I feasibility study, this project proposes the development of a new material: a calcium sulfate/absorbable polymer composite with anti-inflammatory properties and bone growth factor delivery capability. Phase I studies have already demonstrated that calcium sulfate/ absorbable polymer composites undergo slower degradation than pure calcium sulfate and thus overcomes a significant drawback of this material as a bone regeneration product. The plan now is to develop a product that dentists can use in bone grafting procedures that will rival the bone regeneration potential seen with the use of the patients own harvested bone. The product, a composite of calcium sulfate and Poly-Aspirin that delivers a bone growth factor, PDGF, utilizes a new polymer whose in vivo bone response has been studied in several animal models. Because of its specific chemical structure, this polymer elicits an excellent cell and tissue response and has an anti-inflammatory effect of great value in the oral environment. Since an earlier version of this product has already been commercialized, this new product will be rapidly introduced to the marketplace and an improved replacement. PUBLIC HEALTH RELEVANCE: Bone grafting is an essential component of facial and dental maintenance. Recent concern about allograft bone supply makes the development of a reliable, affordable synthetic essential to this process. This project describes the development of just such a synthetic with bone regeneration capability rivaling autografts based on a simple, affordable material with a long safety history, calcium sulfate, combined with an anti-inflammatory absorbable polymer and a bone growth factor.
描述(申请人提供):这项研究的目的是开发一种用于牙科的改进的、合成的骨移植材料。牙齿的缺失往往伴随着颌骨的缺失。修复这块丢失的骨骼通常是安装牙种植体和保持正常面部特征的先决条件。作为一种骨再生材料,硫酸钙效果很好。它不仅可以作为缺损处的填充物,而且具有生物相容性,可以引导新骨生长,促进新血管的生长。然而,其降解速度快是其主要缺点,限制了其在骨移植中的应用。在第一阶段可行性研究成功的基础上,该项目建议开发一种新材料:一种具有抗炎性能和骨生长因子输送能力的硫酸钙/可吸收聚合物复合材料。第一阶段的研究已经证明,硫酸钙/可吸收聚合物复合材料的降解速度比单纯的硫酸钙慢,因此克服了这种材料作为骨再生产品的一个显着缺陷。现在的计划是开发一种产品,牙医可以在骨移植过程中使用,这种产品将与使用患者自己收获的骨看到的骨再生潜力相媲美。该产品是硫酸钙和聚阿司匹林的混合物,可提供骨生长因子PDGF,使用一种新的聚合物,其体内骨反应已在几个动物模型中进行了研究。由于其特殊的化学结构,该聚合物可引起良好的细胞和组织反应,并在口腔环境中具有重要的抗炎作用。由于该产品的早期版本已经商业化,这一新产品将迅速推向市场,并推出改进的替代品。公共卫生相关性:骨移植是面部和牙齿维护的重要组成部分。最近对同种异体骨供应的关注使得开发一种可靠的、负担得起的合成材料对这一过程至关重要。该项目描述了这样一种具有骨再生能力的合成材料的开发,该材料基于一种简单、负担得起的、具有长期安全历史的材料--硫酸钙,结合抗炎可吸收聚合物和骨生长因子。

项目成果

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Harold Alexander其他文献

Harold Alexander的其他文献

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{{ truncateString('Harold Alexander', 18)}}的其他基金

Multiphasic Calcium Sulfate Bone Repair Material
多相硫酸钙骨修复材料
  • 批准号:
    6832895
  • 财政年份:
    2004
  • 资助金额:
    $ 38.29万
  • 项目类别:
Calcium Sulfate Based Bioactive Bone Graft
硫酸钙基生物活性骨移植物
  • 批准号:
    7688597
  • 财政年份:
    2004
  • 资助金额:
    $ 38.29万
  • 项目类别:
Calcium Sulfate Based Bioactive Bone Graft
硫酸钙基生物活性骨移植物
  • 批准号:
    7830703
  • 财政年份:
    2004
  • 资助金额:
    $ 38.29万
  • 项目类别:
Laser-Engineered Net Shape Ti/HA Composite Implants
激光设计的净形状 Ti/HA 复合植入物
  • 批准号:
    6443481
  • 财政年份:
    2002
  • 资助金额:
    $ 38.29万
  • 项目类别:
A Mechanical/Neural Limb Prosthetic Interface
机械/神经假肢接口
  • 批准号:
    6620218
  • 财政年份:
    1995
  • 资助金额:
    $ 38.29万
  • 项目类别:
A Mechanical/Neural Limb Prosthetic Interface
机械/神经假肢接口
  • 批准号:
    6405234
  • 财政年份:
    1995
  • 资助金额:
    $ 38.29万
  • 项目类别:

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