New Fluorinated MRI Probes for Cell Imaging

描述（由申请人提供）：提出了用于磁共振成像（MRI）的新型生物相容性探针。基于19F的探针将比现有产品更适合使用19F MRI进行快速和敏感的氧定位。这些探针将用于在模型系统中评估大鼠INS-1细胞的活力、代谢率和耗氧量，作为人类INS-1细胞的替代品，用于糖尿病治疗的潜在应用。试点研究的初步数据表明，这些新的探针是有希望的，并构成了一个可行的方法，以改善细胞活力控制。

DESCRIPTION (provided by applicant):New bio compatible probes are proposed for magnetic resonance imaging (MRI). 19F based probes will be prepared that are more suitable than existing products for rapid and sensitive oxygen mapping using 19F MRI. These probes will be employed to assess in a model system the viability, metabolic rate and oxygen consumption rates of rat INS-1 cells as surrogates of human is lets for potential applications in diabetes therapy. Preliminary data from pilot studies indicate that these new probes are promising and constitute a viable approach for improved cell viability control.