Electrochemical Umpolung Arylation of Ketones

α-芳基化羰基部分的合成是重要的，因为它们广泛分布在生物活性药物中，包括HIV和非甾体抗炎药。目前安装这种结构的方法需要具有预安装功能的构件，这增加了成本和产生的废物。使用未官能化的底物的方法是一个未解决的问题。通过利用电化学氧化策略，我们将开发新的α-芳基化方法，使用未官能化的底物，这将是更便宜，产生更少的废物，并扩大以前的协议的范围。通过提高效率，合适底物的可用性和扩大该反应产物的范围，可以增强药物发现所依赖的化学空间。这个项目是及时的，因为电化学氧化还原过程在工业和学术界越来越受欢迎，因为它们具有高度的可持续性和选择性。

The synthesis of a-arylated carbonyl moieties is important because they are wide-spread throughout bio-active pharmaceuticals, including HIV and non-steroidal anti-inflammatory drugs. Current methods to install this structure require building-blocks with pre-installed functionality, which increases the cost and waste generated. Methods that employ unfunctionalised substrates is an unsolved problem. By exploiting an electrochemical oxidation strategy, we will develop new a-arylation methods that use unfunctionalised substrates, which will be more inexpensive, produce less waste and expand the scope of previous protocols. By increasing the efficiency, availability of suitable substrates and widening the scope of products from this reaction, the chemical space- from which the discovery of drugs rely- can be enhanced. This project is timely, because electrochemical redox processes are becoming increasingly popular in industry and academia as they are highly sustainable and selective.