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EFFECT OF ANTIRESORPTIVES IN PATIENTS W/ PAGETS DISEASE

EFFECT OF ANTIRESORPTIVES IN PATIENTS W/ PAGETS DISEASE
抗吸收剂对佩吉特病患者的影响
批准号：
6586814
负责人：
JAN M BRUDER
金额：
$23.48万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-12-01 至 2002-11-30
来源：
https://reporter.nih.gov/project-details/6586814
关键词：
alendronate clinical research diphosphonate human subject human therapy evaluation interleukin 6 longitudinal human study measles virus osteitis deformans osteoclasts pathologic bone resorption physiologic bone resorption skeletal disorder chemotherapy

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中文摘要
翻译
佩吉特氏症是一种骨重塑疾病。这个过程是由破骨细胞介导的骨吸收的增加开始的，随后是大量新的但异常的骨形成。本研究将测定Paget病患者外周血中破骨细胞前体的数量、IL-6水平和麻疹病毒核衣壳mRNA的存在或不存在，这些患者在接受抗吸收双磷酸盐阿仑膦酸盐治疗开始时和6个月治疗结束时。破骨细胞前体的数量和IL-6水平将与疾病的活动相关，这是由骨吸收和形成的血清和尿液标志物的水平决定的。
英文摘要
Paget's is a disorder of bone remodeling. The process is initiated by an increase in osteoclast mediated bone resorption followed by an abundance of new but abnormal bone formation. This study will determine the number of osteoclast precursors, the level of IL-6 and the presence or absence of measles virus nucleocapsid mRNA in the peripheral blood from patients with Paget's disease at the start of their scheduled treatment with the antiresorptive bisphosphonate alendronate and at the completion of the 6 month treatment. The number of osteoclast precursors and the IL-6 levels will be correlated with the activity of the disease as determined by the levels of serum and urine markers of bone resorption and formation.
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