Investigating the immune response to breast cancer stem cell antigens: implications for cancer diagnosis and therapy.

针对肿瘤抗原的抗体普遍存在于患者血清中，可作为强有力的诊断工具。在我们的实验室中，我们已经确定了针对癌症干细胞抗原的自身抗体可以在乳腺癌患者的血清中检测到。该项目旨在调查三阴性乳腺癌（一种侵袭性癌症，影响年轻妇女，没有早期发现方法和靶向治疗）患者自身抗体的检测情况。我们的目标是在免疫反应的基础上识别抗原，这些抗原可用于开发针对这种侵袭性癌症的新诊断和有效疗法。

Antibodies against tumour antigens are commonly found in serum of patients and they can be used as powerful diagnostic tool. In our laboratory, we have established that autoantibodies against cancer stem cell antigens can be detected in breast cancer patient sera. This project aims to investigate the detection of autoantibodies in patients affected by triple negative breast cancer (a type of aggressive cancer that affects younger women and for which there is no early detection method and targeted therapy). We aim to identify the antigens at the basis of the immune response that can be used to develop novel diagnostics and effective therapies for this aggressive type of cancer.