Core--Lung imaging

（申请人的摘要）成像的最新进展现在为我们提供了一种新的成像方法。 这是一个绝佳的机会， 细胞功能和患者气道生理之间的关系 哮喘成像核心的主要使命是将 呼吸道结构、生理学和病理学与招募的功能 cell.从人类和动物研究中获得的成像数据将 与项目I-V中获得的生理和细胞数据相关。 具体目的是：1）评估嗜酸性粒细胞对气道的影响 超极化氦-3（3 He）MR肺通气生理学研究 在人类和动物哮喘模型中，2）确定区域分布 在人类和动物哮喘模型中的代谢活性嗜酸性粒细胞， 18FDG PET，以及3）共配准来自PET的代谢和生理数据， 使用肺部高分辨率CT扫描的解剖信息进行MRI。 由于许多建议的技术是新的，核心C将负责 开发和执行所提出的成像方法。

(Applicant's Abstract) Recent advances in imaging now provide us with an outstanding opportunity to improve our knowledge about the relationship between cellular function and physiology of the airspaces in patients with asthma. The primary mission of the Imaging Core is to correlate changes in airway structure, physiology, and pathology with function of the recruited cell. The imaging data gained from the human and animal studies will be correlated with physiologic and cellular data obtained in Projects I-V. Our specific aims are to; 1) evaluate the influence of eosinophils on airway physiology using hyperpolarized helium-3 (3He) MR imaging of lung ventilation in human and animal models of asthma, 2) determine the regional distribution of metabolically active eosinophils in human and animal models of asthma using 18FDG PET, and 3) co-register the metabolic and physiologic data from PET and MRI using anatomic information from high-resolution CT scanning of the lungs. Since many of the proposed techniques are new, CORE C will be responsible for developing and performing the proposed imaging methods.