Functional evaluation of renal artery stenosis using MRI

描述（来自申请人摘要的逐字）：肾血管疾病是一种 是高血压和肾缺血重要原因。在六千万美国人中 在高血压患者中，1 - 5%有肾血管病因。此外，本发明还提供了一种方法， 据估计，15%的严重肾功能衰竭患者 动脉狭窄（RAS）和缺血性肾病。长期目标是 该项目是为了改善血管疾病患者的预后， 肾脏，如肾血管性高血压和缺血性肾病。 虽然有几种技术可以评估解剖结构或功能 肾动脉疾病重要性是可用的，没有单一的方法能够 提供有关解剖和功能的明确信息， 与此同时，磁共振成像（MRI）评价 相对于现有技术，RAS具有几个潜在的优点。的 该项目提出的方法提供了一种快速和微创的 用于评估目前每个肾脏中的肾功能的技术 这是任何其他技术都无法实现的。我们建议继续发展 MRI方法测定肾小球滤过率是一项重要的测量指标 的肾功能，在一系列的体外和体内实验。 首先，我们建议开发和验证一种新的方法，用于确定肾 提取分数（EF）使用快速反转恢复MRI技术。 其次，我们将开发并验证一种测量肾血流量的方法 (RBF)在体内，其能够具有比在体内更高的空间和时间分辨率， 现有技术。最后，我们将测量RBF、EF和单个 血管紧张素转换后肾小球滤过率（skGFR） 肾血管性高血压猪模型中的ACE抑制， 缺血性肾病如果成功，本研究中开发的方法将 导致对RAS生理效应的新理解，并将有助于 指导人体实验。

DESCRIPTION (Verbatim from Applicant's Abstract): Renal vascular disease is an important cause of hypertension and renal ischemia. Of the 60 million Americans with hypertension, 1 - 5 percent have a renal vascular etiology. In addition, an estimated 15 percent of all patients with severe renal failure have renal artery stenosis (RAS) and ischemic nephropathy. The long-term objective of this project is to improve the prognosis of patients with vascular diseases of the kidney, such as renovascular hypertension and ischemic nephropathy. While several techniques that evaluate either the anatomy or functional significance of renal artery disease are available, no single method is capable of providing unambiguous information regarding both the anatomic and functional significance of RAS simultaneously. Magnetic resonance imaging (MRI) evaluation of RAS has several potential advantages relative to existing techniques. The method proposed in this project provides a rapid and minimally invasive technique for evaluating the renal function in each kidney that is currently not available from any other techniques. We propose to continue developing an MRI method for determining glomerular filtration rate, an important measurement of renal function, in a series of in vitro and in vivo experiments. First, we propose to develop and validate a novel method for determining renal extraction fraction (EF) using a fast inversion-recovery MRI technique. Secondly, we will develop and validate a method for measuring renal blood flow (RBF) in vivo that is capable of higher spatial and temporal resolution than existing techniques. Finally, we will measure changes in RBF, EF, and single kidney glomerular filtration rate (skGFR) following angiotensin converting enzyme (ACE) inhibition in swine models of renovascular hypertension and ischemic nephropathy. If successful, the method developed in this study will lead to a new understanding of the physiologic effects of RAS, and would help guide experiments in humans.