Environmental regulation of virulence in attaching and effacing enterobacteria

致病细菌必须对它们在宿主体内遇到的极端条件(如酸和胆汁)做出反应。它们通过感知环境和激活基因来实现这一点，这些基因提高了它们的存活率和致病能力。在这个项目中，我们将使用大肠杆菌作为模型，定义这些感知和反应途径发生的机制。从这项研究中获得的信息应该会导致治疗和预防细菌感染的新策略。

Disease-causing bacteria must respond to the extreme conditions, such as acid and bile, which they encounter in their hosts. They achieve this by sensing their environment and activating genes that enhance their survival and ability to cause disease. In this project we will define the mechanisms by which these sensing and response pathways occur, using E. coli as a model. The information obtained from this research should lead to new strategies to treat and prevent bacterial infections.