CORE--CLINICAL

描述（由申请人提供）： 临床核心将通过提供护理和其他人员来支持项目1-5， 最具成本效益的方式招募和筛选正常受试者， 通过个体表现对特定自主神经紊乱患者进行表型分型 研究和维护自主神经功能障碍中心数据库。共享自习 房间和设备最大限度地提高了资源的可用性， 在研究和数据分析中的表现。核心人员参与这些活动 研究将提高每个项目从其他项目获得的数据中获益的能力 项目核心将支持最先进的交感神经功能评估 活动在人（去甲肾上腺素溢出，显微神经摄影术，频谱分析的生理 信号），心输出量测定，绝对测量的多种方法 血浆容量和液体变化，并支持专门的分析方法 压力反射功能的表征（包括颈部抽吸压力反射测试）。芯会 还提供氚化去甲肾上腺素（批量购买时使用成本效益更高） 和显微神经学用品。

DESCRIPTION (provided by applicant): The Clinical Core will support Projects 1-5 by providing nursing and other personnel to support in the most cost-effective manner the recruitment and screening of normal subjects, the phenotyping of patients with specific autonomic disorders by the performance of individual studies and the maintenance of the Autonomic Dysfunction Center Database. Shared study rooms and equipment maximize the availability of resources and provide consistency in the performance of studies and in data analysis. The involvement of Core personnel in these studies will enhance the ability of each Project to benefit from the data obtained in the other Projects. The Core will support state-of-the-art functional assessment of sympathetic nerve activity in man (norepinephrine spillover, microneurography, spectral analysis of physiological signals), cardiac output determination, multiple methods for the measurement of absolute plasma volume and fluid shifts, and support for specialized analytic methods for the characterization of baroreflex function (including neck suction baroreflex testing). The Core will also provide tritiated norepinephrine (more cost-effectively utilized when purchased in bulk) and microneurography supplies.