Nine mega-pixel digital mammography display workstation

描述(由申请人提供)：第一阶段：本申请致力于开发和评估9兆像素数字乳房X光摄影工作站。长期目标是为放射科医生提供高分辨率、高亮度、最先进的审查工作站，以提高全视野数字乳房X光检查的临床接受度。实现这一目标的关键是实施图像质量优于当前CRT显示器的显示器解决方案，并由一个软件工具集成平台支持，以确保轻松的考试流程和高效的考试审查。以下具体目标与本申请的第一阶段有关。(1)修改当前审查工作站，以实现用于进行AMLCD平板物理表征的原型平板工作站。(2)平台架构和软件规范的开发。(3)根据美国物理学家协会制定的标准指南完成平板表征任务组18。(4)最佳亮度工作点和相关参数的定义，用于最佳显示灰度级乳房X光照片。(5)开发工作站高级功能规格，包括双平板显示器和自动平板在横向和纵向模式之间旋转。 第二阶段：该应用程序致力于开发和评估900万像素的数字乳房X光摄影工作站。长期目标是为放射科医生提供高分辨率、高亮度、最先进的审查工作站，以提高全视野数字乳房X光检查的临床接受度。实现这一目标的关键是实施图像质量优于当前CRT显示器的显示器解决方案，并由一个软件工具集成平台支持，以确保轻松的考试流程和高效的考试审查。以下具体目标与本申请的第二阶段有关。(L)系统设计与集成。阶段IT工作的很大一部分将致力于与实施第一阶段定义的审查工作站架构和软件相关的工程开发工作。RWS的主要组件包括主计算机、图形适配器车、图形卡的软件驱动程序和主要应用软件。(2)系统优化：进行心理物理实验，以确定独特的LCD特性对视觉感知的影响(包括定义最佳图像显示的亮度工作范围)。(3)检查流程的临床前评估和优化。(4)临床验证：乳房X光检查筛查检查的读者研究，在两种情况下进行：使用CRT显示器和使用平板显示器。测量的结果将是ROC曲线下的面积、敏感性、特异性和解释时间。

DESCRIPTION (provided by applicant): Phase I: This application is devoted to the development and evaluation of a nine mega-pixel digital mammography workstation. The long-term objective is to provide radiologists with a high-resolution, high-luminance, state-of-the-art review workstation to improve the clinical acceptance of full-field digital mammography. Essential to the realization of this objective is the implementation of display solutions with image quality superior to that of current CRT displays, supported by an integrated platform of software tools to guarantee easy examination flow and efficient examination review. The following specific aims pertain to phase I of this application. (1) Modification of a current review workstation to implement a prototype flat-panel workstation from which to conduct the AMLCD flat-panel physics characterization. (2) Development of the platform architecture and software specifications. (3) Complete flat-panel characterization per the standard guidelines developed by the American Association of Physicists in Medicine task group 18. (4) Definition of the optimal luminance operating points and associated parameters, for optimal display of grayscale mammograms. (5) Development of the workstation advanced functionality specifications, including dual flat-panel display and automatic flat-panel rotation between landscape and portrait mode. Phase II: This application is devoted to the development and evaluation of a nine mega-pixel digital mammography workstation. The long-term objective is to provide radiologists with a high-resolution, high-luminance, state-of-the-art review workstation to improve the clinical acceptance of full-field digital mammography. Essential to the realization of this objective is the implementation of display solutions with image quality superior to that of current CRT displays, supported by an integrated platform of software tools to guarantee easy examination flow and efficient examination review. The following specific aims pertain to phase II of this application. (l) System design and integration. A significant part of the phase IT efforts will be devoted to engineering development work associated with the implementation of the review workstation architecture and software as defined in phase I. The main components of the RWS include the main computer, the graphics adapter cars, the software drivers for the graphics cards, and the main application software. (2) System optimization: psychophysics experiments to ascertain the impact of unique LCD characteristics on visual perception (including definition of the luminance operating range for optimal image display). (3) Pre-clinical evaluation and optimization with respect to the examination process flow. (4) Clinical validation: reader study for the mammography screening exam, conducted under two conditions: with CRT displays, and with fiat-panel displays. The measured outcomes will be area under the ROC curve, sensitivity, specificity, and interpretation time.