EMOTIONS

描述（由申请人提供）：额颞叶变性（FTLD） 和阿尔茨海默氏病（AD）是两种常见的痴呆症形式，两者都 在临床诊断和患者管理中存在重大问题。在 在FTLD的早期阶段，许多症状是行为性的，包括 情感行为、社会行为和个性的变化。这些 行为症状尚未明确，因此FTLD经常 未被识别或误诊。在AD的早期阶段， (e.g，记忆丧失）最为突出，但社会情感行为的变化 个性可能会在以后发展。与FTLD一样， 这些社会情绪和人格的变化在AD中是缺乏的。 我们建议评估应用基本开发方法的效用 行为研究，以实现更全面的评估情绪， 社会行为和个性在这两种临床综合征中的作用。这 评估将衡量：（a）实际的情绪行为，因为它发生（作为 反对仅仅依靠回顾性报告）;（B）主要情绪 功能，包括情绪反应，情绪调节和情绪 （c）情绪的主要类别，包括负面情绪、正面情绪、负面 情绪和自我意识的情绪;（d）不同的背景下， 情绪发生，包括当人独自一人，并作出反应， 刺激以及当人处于有意义的社会环境中时（例如， 与所爱的人互动）;（e）多种情绪指标，包括 主观经验、表达行为和自主神经系统 生理学;（f）随着时间的推移发生的情绪功能变化;以及（g） 性格的变化。 该研究涉及四个具体目标：（a）使用源自 基本的行为研究来评估情绪反应的变化， FTLD和AD的情绪调节、情绪知识和人格特征; (b)评估FTLD的遗传标记与FTLD的关系， 在有积极历史的家庭中， FTLD;（c）评估大脑特定区域之间的关系 情绪行为的退化和伴随的变化;以及（d）评估 FTLD和AD患者社会情绪行为变化的研究 与配偶的互动。描述社会情绪和人格变化 有助于更准确、更早的诊断; 这些疾病的重要亚型;并帮助我们更好地处理 这些疾病对患者的生活及其 家庭

DESCRIPTION (provided by applicant): Frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD) are two common forms of dementia, both of which present significant problems in clinical diagnosis and patient management. In the early stages of FTLD, many of the symptoms are behavioral, including changes in emotional behavior, social behavior, and personality. These behavioral symptoms have not been well-specified, and thus FTLD often goes unrecognized or misdiagnosed. In the early stages of AD, cognitive changes (e.g, memory loss) are most prominent, but changes in socio-emotional behavior and personality may develop later. As with FTLD, tools for precisely assessing these socio-emotional and personality changes in AD are lacking. We propose to evaluate the utility of applying methods developed in basic behavioral research to achieve a more comprehensive assessment of emotion, social behavior, and personality in these two clinical syndromes. This assessment will measure: (a) actual emotional behavior as it occurs (as opposed to solely relying on retrospective reports); (b) major emotional functions, including emotional reactivity, emotional regulation, and emotional knowledge; (c) major classes of emotion, including negative emotions, positive emotions, and self-conscious emotions; (d) different contexts in which emotions occur, including when the person is alone and responding to wellspecified stimuli and when the person is in meaningful social contexts (e.g., interacting with a loved one); (e) multiple indicators of emotion, including subjective experience, expressive behavior, and autonomic nervous system physiology; (f) changes in emotional functioning that occur over time; and (g) changes in personality. The research addresses four specific aims: (a) to use methods derived from basic behavioral research to evaluate changes in emotional reactivity, emotional regulation, emotional knowledge, and personality in FTLD and AD; (b) to evaluate the relationship that purported genetic markers of FTLD have with emotional behavior and personality in families with a positive history of FTLD; (c) to evaluate relationships between specific regions of brain degeneration and attendant changes in emotional behavior; and (d) to evaluate changes in socio-emotional behavior in FTLD and AD patients by studying dyadic interaction with spouses. Delineating socio-emotional and personality changes in dementia can contribute to more accurate, earlier diagnosis; to identifying important subtypes of these disorders; and to helping us better deal with the profound impact that these disorders have on the lives of patients and their families.