Core--Animal and general research services

核心B，即动物和一般研究服务核心，将为各个中心项目提供四项具体服务。这些服务包括：动物采购、准备和维护；从实验对象采集、储存和分发组织；开发可供个别项目使用的临床相关的整体动物疼痛模型；以及组织切片中的免疫细胞化学。利用中央核心设施为每个单独的项目提供实验对象，确保了动物品系、供应商、处理程序、手术程序和行为程序的标准化。在一些情况下，核心促进了多个研究人员的互动，这些研究人员将从相同的实验对象获得的组织用于不同的目的。使用中央设施还可以最大限度地减少设备、技术支持和行政工作的重复，例如提交和维护动物护理和使用规程。因此，核心的设计是以最有效的方式使用拟议的资源，为中心内的所有单独实验室提供最大限度的服务。

Core B, the Animal and General Research Services Core, will provide four specific services to the individual center projects. These services are: animal procurement, preparation and maintenance; harvesting, storage and distribution of tissues from experimental subjects; development of clinically relevant whole animal pain models that can be utilized by individual projects; and immunocytochemistry in tissue sections. The utilization of a central core facility to provide experimental subjects to each individual project assures standardization of animal strain, suppliers, handling procedures, surgical procedures, and behavioral procedures. In several instances, the core facilitates the interaction of multiple investigators who will utilize tissue obtained from the same experimental subjects for different purposes. The use of a centralized facility also minimizes duplication of equipment, technical support and administrative effort such as submission and maintenance of animal care and use protocols. The core is therefore designed to use the proposed resources in the most efficient manner to provide the maximum service to all individual laboratories within the center.