Apoptosis of ESNLCs

描述：（摘自摘要）神经系统在正常和病理情况下均发生凋亡细胞死亡。PI的初步数据表明，胚胎干细胞移植到鼠损伤脊髓后，细胞凋亡在移植过程中起主要作用。这一过程中细胞死亡的程度目前尚不清楚。本研究的目的是研究胚胎干细胞来源的神经谱系细胞（ESNLCs）的凋亡细胞死亡。在相关的发展阶段。在第二部分中，他将描述在脊髓细胞凋亡诱导活动中积累的脊髓液的细胞凋亡诱导活性，并确定这种活性随损伤后时间的变化。第三，他将利用在细胞凋亡的分子机制中发展的范式，并开发抗细胞凋亡的细胞系。这些实验应该有助于确定在ESNLC移植成功后负责诱导凋亡的最佳分子。

Description: (from the abstract) Apoptotic cell death occurs in the nervous system during normal and in pathological situations. The PI's preliminary data indicate that apoptosis has a major role in the ES cell graft after transplant into the injured rodent spinal cord. The extent of cell death underlie this process are currently unknown. The goal of this proposal is to apoptotic cell death of ES cell-derived neural lineage cells (ESNLCs). In relevant stages of development. In the second, he will characterize the apoptosis-inducing activity of the syrinx fluid which accumulates in the spinal apoptosis-inducing activity, and determine the changes in this activity as a function of time post-injury. Third, he will utilize the paradigms developed in to the molecular mechanisms of apoptosis and to develop cell clines that are resistant to apoptosis. These experiments should help to define the optimal molecules that are responsible for apoptosis induction seen after the success of ESNLC transplants.