HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.

描述：人类粒细胞性埃立克体病(Hge)是一种新出现的由壁虱传播的疾病。 急性发热病。HGE的药剂与HGE密切相关或相同 马的病原体是马埃立克体病，由肩部硬蜱传播， 同样是传播莱姆病和巴贝斯虫病病原体的扁虱。卫生与公众服务部 制剂感染血液中的中性粒细胞，导致中性粒细胞减少和 一种血小板减少症。HGE可能是一种轻微到可能致命的疾病。HGE是 1994年在明尼苏达州和威斯康星州首次被描述，随后超过 在美国已经描述了400个病例，与莱姆病形成鲜明对比的是 HGE多见于儿童，其发生率及严重程度随年龄增长而增加。 这种特定年龄段的HGE发病率和我们庞大的老龄化人口呈现出 潜在的重大公共卫生问题与相应的经济 后果。这一新出现的公共卫生问题凸显了 预防感染并发症的早期诊断和治疗，以及 将预防和控制研究的目标对准高危人群。这个 本申请中提出的研究旨在帮助实现上述目标 通过分析美国中北部地区HGE的流行病学来实现目标 具体目标是：调查白尾鹿服务的假设 作为大型哺乳动物储藏剂的HGE和鉴别的小型 HGE制剂的哺乳动物储藏库。

DESCRIPTION: Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne acute febrile illness. The agent of HGE is closely related to or identical to the horse pathogen Ehrlichia equi and is transmitted by Ixodes scapularis, the same tick that transmits the agents of Lyme disease and babesiosis. The HGE agent infects blood polymorphonuclear neutrophils resulting in neutropenia and a thrombocytopenia. HGE may be a mild to potentially fatal disease. HGE was first described in Minnesota and Wisconsin in 1994 and subsequently more than 400 cases have been described in the U.S. In contrast to Lyme disease which frequently occurs in children, the rates and severity of HGE increase with age. This age-specific incidence of HGE and our large aging population presents a potentially major public health problem with corresponding economic consequences. This emerging public health problem highlights the importance of early diagnosis and treatment in preventing complications of infection, and targeting of prevention and control studies to populations at highest risk. The research proposed in this application is designed to aid in achieving the above goals by analyzing the epizootiology of HGE in the North Central U.S. Our specific aims are: to investigate the hypothesis that white-tailed deer serve as a large mammal reservoir of the agent of HGE and to identify the small mammal reservoirs of the HGE agent.