POOLING OF PROSPECTIVE STUDIES OF DIET AND CANCER

描述：(申请人提供)在本申请中， 饮食与癌症前瞻性研究联合项目(简称 Pooling Project)将扩大研究饮食与胰腺的关系 和卵巢癌在大规模的前瞻性队列研究中。扩展了 针对这些中等发病率癌症的汇集计划将需要 综合多项研究数据的统计能力优势 以及检查范围广泛的进水口和分组细节的能力。这个 池化分析还允许使用标准化的分析方法 跨研究的暴露和协变量的分类。其他分析 结直肠癌，这是一个正在接受评估的癌症部位 目前的赠款周期，也将进行。这11项研究包括 联合项目是基督复临安息日健康研究，α-生育酚，β-胡萝卜素 癌症预防研究，加拿大国家乳房筛查研究，癌症 预防研究II营养队列，爱荷华州妇女？S健康研究，健康 专业人员跟踪研究，荷兰队列研究，纽约州 队列，纽约大学女性？S健康研究，护士？健康研究，以及 瑞典乳房X光摄影术协会。分析将包括4949例结直肠癌 估计有1,553例胰腺癌和1,908例卵巢癌。为 结直肠癌，与特定的类胡萝卜素和谷物的关系将是 检查过了。对于胰腺癌，分析将评估与 水果、蔬菜、类胡萝卜素、谷物、纤维、酒精、 还有肉。乳糖、乳制品摄入量与卵巢癌风险分析 产品，水果，蔬菜，抗氧化剂，脂肪，鸡蛋和胆固醇 将进行体重指数测试。正在举行的年度会议，并经常 调查人员之间的沟通，将用于促进分析和 对调查结果的解释。这些分析将充分利用 已收集的大量数据为深入了解两者之间的关系提供了有力的支持 饮食与胰腺癌、卵巢癌、结直肠癌风险之间的关系。

DESCRIPTION: (provided by Applicant) In this application, the aims of the Pooling of Prospective Studies of Diet and Cancer Project (referred to as the Pooling Project) will expand to examine dietary associations with pancreatic and ovarian cancers in large, prospective cohort studies. Expansion of the Pooling Project to these cancers with intermediate incidence rates will take advantage of the statistical power from combining data from multiple studies and the ability to examine a wide range of intakes and subgroup detail. The pooled analyses also allow standardized analytic approaches with standardized categorization of exposures and covariates across studies. Additional analyses of colorectal cancer, a cancer site that is being evaluated as part of the current grant cycle, also will be conducted. The 11 studies comprising the Pooling Project are the Adventist Health Study, Alpha-Tocopherol Beta-Carotene Cancer Prevention Study, Canadian National Breast Screening Study, Cancer Prevention Study II Nutrition Cohort, Iowa Women?s Health Study, Health Professionals Follow-up Study, Netherlands Cohort Study, New York State Cohort, New York University Women?s Health Study, Nurses? Health Study, and Sweden Mammography Cohort. Analyses will include 4,949 colorectal cancer cases and an estimated 1,553 pancreatic and 1,908 ovarian cancer cases. For colorectal cancer, associations with specific carotenoids and grains will be examined. For pancreatic cancer, analyses will evaluate associations with intakes of fruits, vegetables, specific carotenoids, grains, fiber, alcohol, and meat. Analyses of ovarian cancer risk and intakes of lactose, dairy products, fruits, vegetables, antioxidants, fat, eggs, and cholesterol and body mass index will be conducted. The ongoing annual meetings, and frequent communication among investigators, will be used to facilitate the analysis and interpretation of the findings. These analyses will take full advantage of extensive data already collected to provide powerful insight into the relation between diet and the risk of pancreatic, ovarian, colorectal cancer.