PHOTODYNAMIC THERAPY--BASIC SCIENCE STUDIES

该计划项目将继续研究光动力疗法 (PDT)。这五个项目将涵盖以下研究课题 细胞对PDT耐药治疗脑部疾病的临床试验 肿瘤。这些项目得到两项核心活动的支持，这两项活动是 对于他们的成功行为来说是不可或缺的。该计划的协同效应将 继续依赖于双方之间的有效互动 科学项目和调查人员。项目1建议 在体内研究可能的方法来提高治疗的有效性。 光动力疗法通过增加肿瘤中氧气的可用性 治疗。项目2建议进行光动力疗法的临床试验 恶性脑瘤。两项涉及Photofrin的试验，一项针对De NOVO和一项针对复发皮损的治疗正在计划中。项目3将 继续研究细胞对光动力疗法的耐药性。关于以下方面的知识 这种抗药性形成的机制对 在细胞水平上理解光动力疗法。项目4将继续 研究光动力疗法剂量学。这项计划中提出的研究将 对光动力疗法的临床应用有直接影响。项目5将 继续其体内研究，以检测PDT在脑肿瘤和 正常的大脑。一个重点领域将是调查替代方案 药物输送方式。CORE将提供全面的技术支持 为了这个项目。设备校准和项目间质量 这个核心将提供保证。

This Program Project will continue to investigate Photodynamic Therapy (PDT). The five projects will cover research topics ranging from cellular resistance to PDT to clinical trials for the treatment of brain tumors. The projects are supported by two core activities which are integral to their successful conduct. The synergy of the Program will continue to depend upon the effective interactions between both the scientific projects and the investigators. Project 1 proposes to investigate, in vivo, possible methods to improve the effectiveness of PDT by increasing availability of oxygen in the tumor at the time of treatment. Project 2 proposes clinical trials of PDT for the treatment of malignant brain tumors. Two trials involving Photofrin, one for de novo and one for recurrent lesions, are planned. Project 3 will continue to investigate cellular resistance to PDT. Knowledge regarding the mechanisms by which such resistance develops is critical to the understanding of PDT at the cellular level. Project 4 will continue to investigate PDT dosimetry. The studies proposed in this project will have a direct impact on the clinical application of PDT. Project 5 will continue its in vivo studies examining PDT effects in brain tumor and normal brain. One area of focus will be to investigate alternate methods of drug delivery. Core will provide overall technical support for the program. Calibration of devices and interproject quality assurance will be provided by this core.