ESTROGEN, INSULIN AND REGIONAL LIPOLYSIS IN OLDER WOMEN

描述（由申请人提供）：由于女性在绝经后体重增加 脂肪优先沉积在腹部，特别是腹部内。 腹部代谢和心血管疾病的风险也会增加 非线性的变化这个研究项目的中心主题 是研究腹腔内脂肪（IAF）和雌激素在 调节女性全身和局部脂肪组织的脂解作用。三 具体目标将针对绝经后妇女的以下假设： 1)IAF体积与胰岛素抑制抵抗相关， 全身和局部脂肪组织的脂肪分解，2）定期使用 雌激素减弱这种对胰岛素抑制脂解的抵抗， 3)IAF的降低将增强胰岛素的抗脂肪分解作用。的 申请人Rachael E.货车佩尔特，博士，目前由个人支持 NRSA从NHLBI，并已表现出一贯的重点和研究记录 生产力在研究年龄，运动，和工作相关的变化， 身体成分、新陈代谢和心血管疾病风险。她的职业目标 是成为一名独立的科学家， 研究计划，继续她在老年学研究的重点。K01 指导研究科学家发展奖将提供博士货车佩尔特 保护研究时间，以获得额外的研究技能， 为实现这一目标所需的经验。除了处理 具体目标的建议，她的培训的一个重要目标是学习 技术上具有挑战性的微透析和高胰岛素血症，血糖正常 夹具程序，并获得进一步的经验，在基本的钳工和 稳定同位素动力学在颁奖期间，货车佩尔特博士将 通过临床科学证书课程在学校的课程 药她还将出席和参加每周一次的研究研讨会， 期刊俱乐部和大型圆桌会议，以及相关的年度科学 会议.货车佩尔特医生的保证人温迪·M Kohrt博士是一位知名的 研究员和导师在老龄化研究，并有一个资金充足的实验室， 科罗拉多健康大学老年医学部 科学中心。她和警局会给货车·佩尔特医生提供 学习环境、资源和技术指导， 顺利完成培训和职业发展。

DESCRIPTION (provided by applicant): As women gain weight after the menopause fat is preferentially deposited in the abdominal, and particularly the intra- abdominal region. Risk of metabolic and cardiovascular disease also increases non-linearly after the menopause. The central theme of this research project is the study of the role of intra-abdominal fat (IAF) and estrogen in the regulation of whole body and regional adipose tissue lipolysis in women. Three specific aims will address the following hypotheses in postmenopausal women: 1) IAF volume is associated with resistance to insulin suppression of lipolysis in whole body and regional adipose tissue, 2) regular use of estrogen attenuates this resistance to insulin suppression of lipolysis, and 3) a reduction in IAF will enhance the antilipolytic action of insulin. The applicant, Rachael E. Van Pelt, PhD, is currently supported by an individual NRSA from NHLBI and has demonstrated a consistent focus and record of research productivity in the study of age-, exercise-, and hormone-related changes in body composition, metabolism and cardiovascular disease risk. Her career goal is to become an independent scientist and to develop an extramurally-funded research program to continue her focus in gerontologic research. The K01 Mentored Research Scientist Development Award would provide Dr. Van Pelt protected research time to obtain the additional research skills and experience necessary to achieve this goal. In addition to addressing the specific aims of the proposal, an important goal of her training is to learn the technically challenging micro dialysis and hyperinsulinemic, euglycemic clamp procedures, and to acquire further experience in basic bench work and stable isotope kinetics. During the award period Dr. Van Pelt will take courses through the Certificate Program in Clinical Science in the School of Medicine. She will also attend and participate in weekly research seminars, journal clubs and grand rounds, as well as relevant annual scientific meetings. Dr. Van Pelt's sponsor, Wendy M. Kohrt, PhD, is an established investigator and mentor in aging research and has a well-funded laboratory in the division of Geriatric Medicine at the University of Colorado Health Sciences Center. She and the department will provide Dr. Van Pelt the rich learning environment, resources, and technical guidance necessary to successfully complete her training and career development.