MECHANISMS OF BETA ADRENERGIC DEFICITS IN AGED RATS

描述（改编自应用程序）： 研究：小脑去甲肾上腺素能系统在运动学习中至关重要 流程. 运动系统的可塑性对老年人很重要 因为许多个体必须适应新的环境和新的移动方式， 在旧环境中;此外， 影响运动系统需要重新学习基本的运动技能。 有一个 老年动物和人类的运动可塑性下降。 理解这一 老年动物可塑性的下降是非常重要的。 下降 与小脑β-肾上腺素能功能的丧失有关。 他们试图了解与年龄相关的生物学机制。 小脑β-肾上腺素能受体功能和相关运动功能下降 行为 他们将研究信号转导机制， β-肾上腺素能受体，使用电生理技术。 氧化 压力已被证明会损害运动学习和β-肾上腺素能 功能 他们还将研究氧化应激和治疗的作用 其改善对β-肾上腺素能功能和运动 在体内和体外学习。 了解的功能基础 运动可塑性和抗氧化治疗的效果显然是至关重要的 制定最佳治疗策略， 人口老龄化。

DESCRIPTION (Adapted from the application): Research: The cerebellar noradrenergic system is critical in motor learning processes. Plasticity in the motor system is important for the elderly because many individuals must adapt to new environments and new ways of moving around in old environments; in addition, rehabilitation from strokes that affect the motor system requires relearning of basic motor skills. There is a decline in motor plasticity in aged animals and humans. Understanding this decline in plasticity in aged animals is of significant importance. A decline in learning is associated with a loss of cerebellar beta-adrenergic function. They seek to understand the biological mechanism underlying the age-associated decline in cerebellar beta-adrenergic receptor function and associated motor behavior. They will examine signal transduction mechanisms of the beta-adrenergic receptor using electrophysiological techniques. Oxidative stress has been shown to impair both motor learning and beta-adrenergic function. They will also examine the role of oxidative stress and treatments that ameliorate oxidative stress on beta-adrenergic function and motor learning both in vivo and in vitro. Understanding the functional basis for motor plasticity and the effects of antioxidant therapy is clearly critical for the development of optimal therapeutic strategies for rehabilitation of the aging population.