Psychosocial Issues in Umbilical Cord Blood Donation

随着医学的不断进步，干细胞移植继续成为治疗恶性血液病、骨髓衰竭综合征和实体瘤癌症的更成功的选择，对由无关捐赠者提供的此类细胞的需求将会增加。尽管这些干细胞传统上是由活体无关的骨髓捐赠者提供的，这些捐赠者可能面临巨大的身体和心理风险，但目前正在探索收集干细胞的新程序，可能会降低捐赠者的风险。其中一个程序涉及从最近生下健康婴儿的母亲那里收集脐带血。尽管美国已经建立了几个公共脐带血库来收集和储存脐带血，但目前还没有关于献血者在捐献过程中和捐献后经历的研究。因此，这项拟议的研究旨在调查公共脐带血库代表接触的母亲的背景、心理社会和与捐赠相关的特征，并要求她们捐赠新生儿的脐带血供未来公共使用。除了描述母亲的特征外，我们还将调查这些特征以及脐血库本身的特征和策略(例如，捐赠者的选择、教育和同意程序)对与捐赠相关的结果(例如，捐献决定、满意度、矛盾心理)的相对影响。横断面问卷数据将在分娩后2-3周或8-9周从1800名母亲那里收集，这些母亲被要求捐献冷血--并由三个公共脐带血库中的一个同意或拒绝献血。此外，将在收集产妇数据的同时收集有关脐带血库的特点和战略的数据。此外，将在收集产妇数据的同时收集有关脐带血库的特点和战略的数据。这些数据将使我们能够(A)描述同意(或不同意)捐赠的母亲的特征，(B)检查母亲的背景、心理社会和与捐赠相关的结果的关系，(C)检查脐带血库战略和组织因素在预测与母亲捐赠相关的结果方面的作用，以及(D)调查母亲和银行的特征对与捐赠相关的结果的协同影响。

As medical advances continue to make the transplantation of stem cells a more successful treatment option for hematologic malignancies, bone marrow failure syndromes, and solid tumor cancers, there will be an increasing need for such cells supplied by unrelated donors. Although these stem cells have traditionally been supplied by living unrelated bone marrow donors who may face significant physical and psychological risks to donate, new procedures of gathering stem cells that may decrease donor risks are currently being explored. One of these procedures involves the collection of umbilical cord blood from mothers who have recently delivered a healthy infant. Although several public cord blood banks have been established in the U.S. to collect and store umbilical cord blood, no studies of donors experiences during and after donation currently exist. Thus, the proposed study is designed to examine the background, psychosocial, and donation-related characteristics of mothers who are approached by representatives of public umbilical cord blood banks and asked to donate their newborn's cord blood for future public use. In addition to description maternal characteristics, we will also investigate the relative influences of these characteristics, and the characteristics and strategies of cord blood banks themselves (e.g., donor selection, education, and consent procedures) on donation-related outcomes (e.g., decision to donate, satisfaction, ambivalence). Cross-sectional questionnaire data will be gathered either 2-3 weeks or 8-9 weeks post delivery from 1,800 mothers who are approached for cold blood donation- and agree or decline to donate by one of three public cord blood banks. In addition, data on cord blood bank characteristics and strategies will be gathered concurrent with maternal data collection. In addition, data on cord blood bank characteristics and strategies will be gathered concurrent with maternal data collection. These data will allow us to (a) describe the characteristics of mothers who agree to (or do not agree to) donate, (b) examine the relationship of maternal background, psychosocial and donation-related outcomes, (c) examine the role of cord blood bank strategies and organization factors in predicting maternal-donation related outcomes, and (d) investigate the synergistic effects of maternal and bank characteristics on donation-related outcomes.