MUSCULOSKELETAL PLASTICITY AFTER SPINAL CORD INJURY

描述(改编自调查者摘要)：次级肌肉骨骼 瘫痪后的并发症增加了人类的痛苦，受损 提高生活质量，增加社会的医疗保健费用。骨骼肌 脊髓损伤后变得高度疲劳，这限制了其功能 用于通过电刺激站立、抓取或行走。 与肌肉疲劳相关的是严重的骨密度损失。从长远来看 该项目的目标是为个人制定锻炼指南。 瘫痪，以防止肌肉骨骼系统的继发性变化。 本项目将描述瘫痪后肌肉骨骼的变化，测试 方法对肌肉骨骼系统进行急性主动加载，并建立 该方法能有效预防或逆转肌肉骨骼改变。 在瘫痪之后。该项目的具体目标是：1)确定 慢性瘫痪的肌肉可以在更长的时间内产生更高的扭矩 在自适应反馈控制下刺激肌肉 恒频开环刺激；2)测定生理 慢性阻塞性肺疾病患者双侧比目鱼肌的特点 在训练前、训练中和训练后6个月，急性和慢性瘫痪 3)测定胫骨骨密度。 急性和慢性骨质疏松症患者的双腿和股骨 单侧肢体运动前、中、后6个月的瘫痪 比目鱼肌。该项目将提供关于 瘫痪后肌肉骨骼系统的可塑性。这样做的好处是 新开发的自适应反馈控制运动可能提供一种标准 瘫痪患者可以使用它来努力保持他们的 瘫痪后的肌肉骨骼特性。

DESCRIPTION (adapted from Investigator's abstract): Secondary musculoskeletal complications following paralysis cause increased human suffering, impaired quality of life, and extended health care costs to society. Skeletal muscle becomes highly fatigable after spinal cord injury, which limits its functional use for standing, grasping, or ambulating with electrical stimulation. Associated with muscle fatigue is a severe loss of bone density. The long term objective of this project is to establish exercise guidelines for individuals with paralysis to prevent the secondary changes to the musculoskeletal system. This project will describe the musculoskeletal changes after paralysis, test a method to actively load the musculoskeletal system acutely, and establish if the method is effective at preventing or reversing the musculoskeletal changes after paralysis. The specific aims of the project are to: 1) determine if chronically paralyzed muscle can produce higher torques for longer times by stimulating the muscle under adaptive feedback control when compared to constant frequency open loop stimulation; 2) determine the physiological properties of the soleus muscle from both lower extremities in individuals with acute and chronic paralysis before, during, and after 6 months of training the unilateral soleus muscle; 3) determine the bone mineral density of the tibia and femur in both lower extremities of individuals with acute and chromic paralysis before, during, and after 6 months of exercising the unilateral soleus muscle. This project will provide empirical evidence about the plasticity of the musculoskeletal system after paralysis. The benefits of this newly developed adaptive feedback controlled exercise may provide a standard that individuals with paralysis may use in an effort to maintain their musculoskeletal properties following paralysis.