Altered mRNA expression after long-term soleus electrical stimulation training in humans with paralysis.
Altered mRNA expression after long-term soleus electrical stimulation training in humans with paralysis.
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DOI：
10.1002/mus.21831
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发表时间：
2011-01
期刊：
影响因子：
3.4
通讯作者：
Shields, Richard K.
中科院分区：
文献类型：
--
作者：
Adams, Christopher M.;Suneja, Manish;Dudley-Javoroski, Shauna;Shields, Richard K.
在人类中，脊髓损伤（SCI）诱导骨骼肌的有害变化，这可以通过电刺激肌肉训练来预防或逆转。肌肉刺激训练的分子机制仍然未知。我们研究了两个独特的SCI受试者，他们的右比目鱼肌接受了>6年的训练（30分钟/天，5天/周）。训练保留了训练腿的扭矩、疲劳指数、收缩速度和横截面积，但未训练腿则不然。训练减少了快速收缩所需的10种mRNA和编码肌肉生长抑制素的mRNA，肌肉生长抑制素是一种抑制肌肉生长的自分泌/旁分泌激素。相反，训练增加了69种介导慢颤、氧化表型的mRNA，包括PGC-1α，一种抑制肌肉萎缩的转录辅激活因子。当我们停止右比目鱼肌训练时，训练引起的效应慢慢减弱;有些持续时间超过6个月。瘫痪肌肉的训练诱导骨骼肌mRNA表达的局部和持久变化，从而改善肌肉质量和功能。
In humans, spinal cord injury (SCI) induces deleterious changes in skeletal muscle that may be prevented or reversed by electrical stimulation muscle training. The molecular mechanisms underlying muscle stimulation training remain unknown. We studied two unique SCI subjects whose right soleus received >6 years of training (30 minutes/day, 5 days/week). Training preserved torque, fatigue index, contractile speed and cross-sectional area in the trained, but not the untrained leg. Training decreased 10 mRNAs required for fast twitch contractions and mRNA that encodes for myostatin, an autocrine/paracrine hormone that inhibits muscle growth. Conversely, training increased 69 mRNAs that mediate the slow twitch, oxidative phenotype, including PGC-1α, a transcriptional co-activator that inhibits muscle atrophy. When we discontinued right soleus training, training-induced effects diminished slowly; some persisted >6 months. Training of paralyzed muscle induces localized and long-lasting changes in skeletal muscle mRNA expression that improve muscle mass and function.
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影响因子：
3.4
作者：
Shields, RK;Chang, YJ;Lin, CH
通讯作者：
Lin, CH
影响因子：
4.8
作者：
Handschin, Christoph;Chin, Sherry;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
3
作者：
Crameri, RM;Weston, AR;Sutton, JR
通讯作者：
Sutton, JR
DOI：
10.1152/ajpendo.00107.2003
发表时间：
2003-10-01
影响因子：
5.1
作者：
Reisz-Porszasz, S;Bhasin, S;Gonzalez-Cadavid, NF
通讯作者：
Gonzalez-Cadavid, NF
DOI：
10.1152/ajpregu.90906.2008
发表时间：
2009-03-01
影响因子：
2.8
作者：
Harber, Matthew P.;Crane, Justin D.;Trappe, Scott W.
通讯作者：
Trappe, Scott W.