HIGH RISK DRUG USE & HIV--LEARNING FROM THE NYC EPIDEMIC

纽约市，大约四分之一的注射吸毒者相关的艾滋病 美国的病例，为研究这一流行病提供了独特的机会 在高危吸毒者中发现艾滋病毒/艾滋病。NDRI进行了关于艾滋病毒的研究 和自1983年以来的高风险药物使用。它目前有9个资助项目 专注于这一主题，因此是一个理想的中心 研究这种流行病。这项提议是为了建立一个P30中心，以提供 基础设施，以增加这些已经获得资金的项目 9个项目的个人和协同研究贡献。 建议使用五个核心来开展以下活动：(1)提供 数据分析和方法支持，包括跨项目、趋势 和二次数据分析，以及开发新的方法；(2) 在人口高发的纽约市建立基于社区的监测能力 社区获取影响社区因素的人种学数据 并监测危险行为和艾滋病毒血清阳性率的趋势 为NDRI正在进行的项目提供信息；(3)进行战略比较 在纽约市和其他国家和国际的疫情之间 社区，以便能够对影响因素进行社区一级的分析 血清阳性、血清发病率和危险行为；(4)培训和 传播职能，包括为受援国培训人员 项目，并将调查结果传播给服务提供商，以及(5) 协调整合资源，提高科学性 互动，支持正在进行的调查和新的调查，集中共同 项目职能，并指导新的调查人员。增加的 NDRI调查人员、项目之间的互动、协作和协同 而通过这些核心职能完成的顾问，将增强 多学科研究，提高 研究人员，使解决新的研究问题成为可能， 产生综合，并导致提高影响和利用率 由此产生的项目结论和建议。

New York City, with approximately one-quarter of all IDU-related AIDS cases in the US, provides a unique opportunity for studying the epidemic of HIV/Aids among high-risk drug users. NDRI has conducted research on HIV and high-risk drug use since 1983. It currently has 9 funded projects focusing on this topic, and is thus ideally situated to house a Center for studying this epidemic. This proposal is for a P30 Center, to provide an infrastructure to these already funded projects, to increase the individual and synergistic research contributions made by the 9 projects. Five Cores are proposed to conduct the following activities: (1) provide data analysis and methodological support, including cross-project, trend and secondary data analyses, and development of new methodologies; (2) establish a community-based monitoring capability in a high prevalence NYC community to obtain ethnographic data on community factors influencing risk and to monitor trends in risk behaviors and HIV seroprevalence to inform NDRI's ongoing projects; (3) undertake strategic comparisons between the epidemic in NYC and other national and international communities, to permit community-level analyses of factors influencing seroprevalence, seroincidence, and risk behaviors; (4) training, and dissemination functions, including training personnel for the supported projects, and dissemination of findings to service providers, and (5) coordination and integration of resource to increase scientific interactions, support ongoing and new investigations, centralize common project functions, and mentor new investigators. The increased interaction, collaboration and synergy across NDRI investigators, projects and consultants as accomplished by these core functions, will enhance multidisciplinary research, increase the productivity of the investigators, make it possible to address new research questions, generate a synthesis and lead to increased impact and utilization of the resultant project conclusion and recommendations.