Functional Outcomes of Cleft Lip Surgery

描述：(摘自摘要)唇腭裂在中国的患病率 美国的活产儿比例约为千分之一(范围为0.7至1.3)。 患有这种先天性出生缺陷的儿童表现出明显的毁容。 指上嘴唇和鼻子。虽然最初的唇裂手术 实现了缺陷的充分关闭，人们普遍认识到 需要额外的(修订)手术以获得最佳的嘴唇形状和 功能。然而，进行这些额外手术的决定是基于 很大程度上取决于手术医生所做的主观临床评估。vt.给出 功能过程中的面部形态对一个人的状态有很大的影响 在社会上感受到，重要的是客观的功能衡量标准 纳入决策过程。目前情况并非如此。 本项目的目标如下：(1)评估项目的得失 静止期和翻唇期的美容与功能损害 手术；(2)测量和量化唇裂患者的面部功能损害 患者；(3)比较客观和主观的功能测量 由有经验的整形外科医生进行评估；及(4)评估 功能相关结果对患者评估的有用性。这个 该项目的研究对象包括唇裂和腭裂两组 在北卡罗来纳大学颅面中心接受治疗的患者：1人 一组将是已被判断为需要唇部整形手术的患者； 第二组是匹配的患者，他们已经被判断为不需要嘴唇 翻修；另一组将与在场的非唇裂患者匹配 在北卡罗来纳大学牙科学校进行常规牙科护理。全球假说 有待检验的是，尽管当代唇部整形手术可能会改善嘴唇 静息状态下，功能可能会进一步受损。 这一假设将通过使用新的方法进行验证，这些方法可以系统地 对裂隙的运动功能、组织生物力学和感觉功能进行量化 和非唇裂受试者。唇部整形手术的疗效将被评估。 在一项前瞻性非随机对照临床试验中。通过比较 动态功能的客观评价与临床疗效判断 进行唇部整形手术的颅面整形外科医生 研究人员将评估新方法在临床上的潜力 申请。要有效地实现本项目的目标， 以经济高效的方式，调查人员利用分包合同 堪萨斯大学和密歇根大学。

DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3). Children born with this congenital birth defect exhibit obvious disfigurement of the upper lip and nose. Although the initial surgery to the cleft lip achieves adequate closure of the defect, it is widely recognized that additional (revision) surgeries are needed to achieve optimal lip form and function. The decision to perform these additional surgeries, however, is based largely on subjective clinical assessments made by the operating surgeon. Given that facial form during function has a major impact on how a person is perceived in society, it is important that objective measures of function be incorporated into the decision making process. This is currently not the case. The goals of this project are the following: (1) to evaluate the gain/loss in esthetics and impairment both at rest and during function of lip revision surgery; (2) to measure and quantify functional facial impairment in cleft patients; (3) to compare objective measures of function to subjective evaluations made by experienced plastic surgeons; and (4) to assess the usefulness of functionally-relevant outcome for patient evaluation. The subjects for this project consist of two groups of cleft lip and palate patients treated at the University of North Carolina Craniofacial Center: one group will be patients who have been judged to need lip revision surgery; the second group will be matched patients who have been judged not to need lip revision; an additional group will be matched non-cleft patients who present for routine dental care at the UNC School of Dentistry. The global hypothesis to be tested is that although contemporary lip revision surgery may improve lip form at rest, function may be further impaired. This hypothesis will be tested by using new methods that can systematically quantify motor function, tissue biomechanics, and sensory functions in cleft and non-cleft subjects. The efficacy of lip revision surgery will be evaluated in a prospective non-randomized controlled clinical trial. By comparing the objective assessments of dynamic function with the clinical judgements of craniofacial plastic surgeons, who perform lip revision surgery, the investigators will evaluate the potential of the new methods for clinical application. To accomplish the goals of this project in an effective and cost-efficient way, the investigators have employed subcontracts with both the University of Kansas and the University of Michigan.