How does the plant regulate receptor signaling to balance immune response and growth?

植物通过检测病原体相关分子模式（PAMP）来感知微生物病原体，这是由细胞表面局部模式识别受体（PRR）介导的。对PAMP的感知触发信号网络，该信号网络包括促分裂原活化蛋白激酶（MAPK）的活化、防御基因表达的活化并最终导致PAMP触发的免疫（PTI）。PAMPs的感知还通过大多数未知的信号传导事件导致生长抑制。由于生长的调节也涉及受体介导的植物肽的感知，因此存在交叉调节的潜力。已经确定了一些联系，表明PRR信号和植物肽信号之间共享一些信号成分，例如在辅助受体BAK1（1）。此外，植物肽的感知最近也与防御反应的负调节有关，并抑制对微生物病原体的抗性（2，3）。目前的项目研究PRR信号和植物肽信号控制生长之间的联系。在目前的项目中，基于受体的信号事件将与先进的蛋白质组学方法和细胞生物学（使用共聚焦显微镜）进行研究。该项目还将涉及分子生物学和蛋白质生物化学，允许对候选人进行广泛的培训。

Plants sense microbial pathogens through the detection of pathogen associated molecular patterns (PAMP) and this is mediated by cell surface localised pattern recognition receptors (PRR). Perception of PAMPs triggers a signaling network that includes activation of mitogen activated protein kinases (MAPK), activation of defence gene expression and ultimately leads to PAMP triggered immunity (PTI). Perception of PAMPs also leads to growth inhibition, by mostly unknown signaling events. Since the regulation of growth also involves receptor-mediated perception of plant peptides there is potential for cross regulation. Some connections have already been identified that suggest some of the signaling components are shared between PRR signaling and plant peptide signaling, such at co-receptor BAK1 (1). Furthermore, perception of plant peptides has recently also been linked to negative regulation of defense response and suppresses resistance to microbial pathogens (2,3). The current project investigates the links between PRR signaling and plant peptide signaling controlling growth. In the current project the receptor based signaling event will be studied with advanced proteomics approaches and cell biology (using confocal microscopy). The project will also involve molecular biology and protein biochemistry allowing for a broad training of the candidate.