Epigenetic regulation of thyroid function

甲状腺激素是发育和新陈代谢的调节剂。同卵双胞胎的甲状腺功能和疾病缺乏一致性，表明环境影响具有重要作用。量化表观遗传修饰，如DNA甲基化，有可能确定环境的因果影响。这项研究将提供一个全面的DNA甲基化改变数据库，这将有助于对健康和疾病中的甲状腺功能的重要见解。

Thyroid hormones are regulators of development and metabolism. The lack of concordance of thyroid function and disease in identical twins suggests that environmental effects have a significant role. Quantifying epigenetic modifications, such as DNA methylation, has the potential to identify causal effects from the environment. This research will provide a comprehensive database of DNA methylome alterations that will contribute important insights into thyroid function in health and disease.