Locomotor Adaptation Following Podokinetic Stimulation

描述：（申请人提供） 本研究的主要目的是为了更好地了解 对改变的感觉输入做出的运动适应。拟议 研究的重点是从“脚上”传递的感觉信息在 运动轨迹的适应。最近的研究表明， 足运动刺激（即，在旋转跑步机上原地踏步， 20-40分钟），蒙上眼睛的受试者被要求站在原地或走在一个 静止表面上直线将不知不觉地相对于 空间这种适应，称为足动后旋转（PKAR），有两个 不同的组件： 1)时间常数为5-10分钟的短期效应和2）长期效应 时间常数为1-2小时。对PKAR有更全面的了解 可能有助于为有平衡能力的人制定康复策略， 和步态障碍。拟议的实验将使用足动刺激 作为评估改变的感觉输入对控制的影响的一种手段， 运动过程中的方向。具体目标I检查运动学和 PKAR的肌电图特征。具体目标2解决了 向前行走对其他行为和要求的适应性的普遍性 左右肢体是否能独立适应。具体目标3 探讨小脑在获得和维持 对足动力刺激的运动适应

DESCRIPTION:(provided by applicant) The major objective of this research is to gain a better understanding of locomotor adaptations made in response to altered sensory inputs. The proposed studies focus on the role of sensory information relayed from the "feet up" in the adaptation of locomotor trajectory. Recent work has shown that, following podokinetic stimulation (i.e., stepping in-place on a rotating treadmill for 20-40 minutes), blindfolded subjects asked to step in-place or walk in a straight line on a stationary surface will unknowingly rotate relative to space. This adaptation, called podokinetic after-rotation (PKAR), has two distinct components: 1) a short-term effect with a time constant of 5-10 minutes and 2) a long-term effect with a time constant of 1-2 hours. A more complete understanding of PKAR may be useful for developing rehabilitation strategies for people with balance and gait disorders. The proposed experiments will use podokinetic stimulation as a means of assessing the effects of altered sensory inputs on the control of orientation during locomotion. Specific Aim I examines the kinematic and electromyographic features of PKAR. Specific Aim 2 addresses the generalizability of adaptations of forward walking to other behaviors and asks whether the left and right limbs can be independently adaptated. Specific Aim 3 explores the role of the cerebellum in the acquisition and maintenance of locomotor adaptations to podokinetic stimulation