Epigenomic marks as indicators of the kinetics of gene activation in immune cells.

启动免疫反应涉及免疫细胞基因表达程序的重大变化。这些基因表达的变化发生在DNA包装到细胞核中的染色质结构中。我们将研究染色质和基因表达变化之间的关系，以及这种关系如何在免疫反应的时机中发挥作用。这些信息将有助于开发控制异常免疫反应的新方法。

Switching on an immune response involves major changes in the gene expression program of the immune cells. These changes in gene expression take place in the context of DNA packaged into the nucleus in a structure known as chromatin. We will investigate the relationship between chromatin and gene expression changes and how this relationship plays a role in the timing of the immune response. This information will be useful in developing novel means of controlling aberrant immune responses.