Modeling critical parameters of the intramuscular injection site

包括长效注射库和皮内装置在内的新型肠外给药技术对于优化药物疗效和减少注射频率的处方策略变得越来越重要。目前，体外工具无法准确模拟这些不同肠外途径的体内表现，特别是肌肉内注射（IM）。这种生物预测工具将有助于指导科学家进行最佳配方制备，并有助于减少对临床前体内数据的依赖，这些数据生成成本高，延迟了产品开发周期，而且往往不能预测临床结果。巴斯大学Mrsny教授实验室的研究导致了一种新方法（剪刀）的发展，以模拟皮下注射部位的生理动力学。葛兰素史克为我亚当·麦卡坦（Adam McCartan）提供了博士奖学金，以支持在IM注射部位识别控制药物命运的参数，目标是建立一种类似于剪刀系统的工具。我将在一个高度应用的环境中接受多学科的培训，并积极参与巴斯大学和GSK之间的知识转移。

Novel parenteral delivery technologies including long acting injection depots and intradermal devices have becomeincreasingly important to formulation strategies to optimize drug efficacy while minimizing injection frequency. Atpresent, in vitro tools fail to accurately model in vivo performance for these various parenteral routes, particularly forintra-muscular (IM) injections. Such bio-predictive tools would help guide scientists towards optimal formulationpreparation and would help reduce reliance on preclinical in vivo data which is costly to generate, delays the productdevelopment cycle, and too often, is not predictive of clinical results. Studies in the laboratory of Professor Mrsny atthe University of Bath have led to the development of a novel method (Scissor) to simulate physiological dynamics ofthe hypodermis, the site of subcutaneous injections. GSK has funded a PhD studentship for me, Adam McCartan, tosupport the identification of parameters that control drug fate at an IM injection site with the goal of setting up a toolsimilar to the Scissor system. I will receive multi-disciplinary training in a highly-applied environment, and be activelyinvolved in knowledge transfer between the University of Bath and GSK.