AFFECTIVE DYSFUNCTION IN SCHIZOPHERNIA

描述：（改编自申请人的摘要） 一项研究是通过聚合来检查精神分裂症患者的情绪处理 神经行为、结构和功能的神经成像方法。情感 功能障碍被认为是精神分裂症的主要缺陷。进展 提供了前所未有的工具来探索神经生物学， 健康人的情绪处理，并以更高的精度确定 导致精神分裂症患者功能障碍的机制这 对理解疾病的表现、病程和治疗 精神分裂症患者的反应。 拟议的调查路线将评估情绪处理应用三维 面部表情和情绪的刺激。这一神经行为领域将是 与神经认知过程和临床测量有关， 症状和功能，特别强调情感状态。大脑的行为 将通过同时进行的神经解剖学评价与 磁共振成像（MRI）和更具体的神经行为探针 使用功能性磁共振成像（fMRI）。解剖学研究允许体积测量 额颞叶结构与情绪调节有关。的 神经行为任务开发来剖析情绪和认知过程 将作为神经行为探针应用于在线测量大脑 功能性磁共振成像。这将提供对大脑系统的评估， 在任务执行过程中，相对于具有 在这些任务上表现出缺陷的精神分裂症。 通过研究受影响家庭成员应用遗传策略 具有神经行为范例的先证者将允许整合两个 精神分裂症、遗传学和行为学方面的强大研究策略 神经科学，需要评估遗传脆弱性。纵向设计 将允许评估神经行为测量的稳定性， 他们的关系，在摄入量，以病程。

DESCRIPTION: (Adapted from applicant's abstract) The goal of the proposed research is to examine emotion processing in schizophrenia through convergence of neurobehavioral, structural and functional neuroimaging methods. Affective dysfunction has been recognized as a major deficit in schizophrenia. Advances in neuroscience provide unprecedented tools to probe the neurobiology of emotional processing in healthy people and determine with increased precision the mechanism responsible for dysfunction in people with schizophrenia. This has implications for understanding the presentation, course and treatment response of individuals with schizophrenia. The proposed line of investigation will assess emotion processing applying 3-D stimuli of facial expressions of emotions. This neurobehavioral domain will be related to neurocognitive processes and to clinical measures that assess symptoms and function, with special emphasis on affective state. Brain behavior relations will be established by concurrent neuroanatomic evaluations with magnetic resonance imaging (MRI) and with more specific neurobehavioral probes using functional MRI (fMRI). The anatomic studies permit volumetric measures of fronto-temporal structures implicated in the regulation of emotion. The neurobehavioral tasks developed to dissect emotion and cognitive processing will be applied as neurobehavioral probes during online measurements of brain activity with fMRI. This will afford an evaluation of brain systems that are recruited in healthy people during task performance, relative to people with schizophrenia who manifest deficit on such tasks. The application of a genetic strategy by studying family members of affected probands with the neurobehavioral paradigms will permit the integration of two powerful research strategies in schizophrenia, genetics and behavioral neuroscience, needed to assess genetic vulnerability. The longitudinal design will allow assessment of the stability of the neurobehavioral measures and their relation, at intake, to course of illness.