PERSONALITY DISORDER OVER 20YRS--RISKS, COURSE, & IMPACT

显然，大多数人格障碍是在童年、青春期和青年期发展的。虽然这些疾病往往与严重的损害，经验基础的理论影响其发病率和过程才刚刚开始积累。拟议的研究扩大了对自1975年以来接受研究的约800人的纵向研究，这些人到2000年平均年龄为31岁。该队列最初是随机抽样的，并且一直保持着其抽样人群的密切代表性。独特的是，人格障碍（PD）从青春期早期就开始评估，与轴I障碍，广泛的风险和结果。PD已被证明与许多儿童风险相关，1反过来，构成成人I轴障碍和功能障碍的风险。我们的第一个目标是确定在成年后对PD病程的影响。我们将调查早期年龄组中PD症状的下降是否会在20年代后期趋于平稳，以及在儿童和青少年期间评估的风险和保护因素是否会继续对成年中期新发PD或症状持续性产生影响。第二个目的是继续我们的调查轴障碍（CIDI评估）和PD之间的联系，检查合并症可能是由于共同的风险或由于一种疾病对另一种疾病的影响。我们还将调查PD对成人功能的影响，以及对社会经济水平的实现，以及这些影响与共病的轴I障碍的独立性。最后，我们将调查PD对父母和后代的情绪和行为问题的影响。

Clearly, most personality disorders develop over the course of Childhood, adolescence and young adulthood. Although these disorders are often associated with serious impairment, an empirical basis for theories about influences on their incidence and course is only beginning to accumulate. The proposed study extends a longitudinal study of about 800 persons who have been studied since 1975, and who will be an average age of 31 in 2000. The cohort was originally randomly sampled, and has remained Closely representative of the population from which it was sampled. Uniquely, personality disorders (PDs) have been assessed since early adolescence, in conjunction with the Axis I disorders, a broad range of risks, and outcomes. PDs have been shown to be related to a number of childhood risks and1 in turn, to constitute a risk for both adult Axis I disorders and for impairment in function. Our first aim is to identify influences on the course of PDs in the adult years. We will investigate whether the decline in PD symptoms shown in earlier age groups will have leveled off by the late 20's and which risk and protective factors assessed during childhood and adolescence continue to have effects on new onset PD or symptom persistence in middle adulthood. A second aim is to continue our investigation of the connection between Axis disorders (assessed with the CIDI) and PD, examining the extent to which comorbidity may be due to shared risks or due to the prior influence of one kind of disorder on another. We will also investigate the impact of PD on adult function, and on the attainment of socioeconomic level, as well as the independence of these effects from those of comorbid Axis I disorder. Finally, we will investigate the impact of PD on parenting and offspring emotional and behavioral problems.