TRAINING FUTURE GENERATIONS OF MENTAL HEALTH RESEARCHERS

这个R25应用程序是围绕两个总体主题组织的——在基础研究和临床研究之间建立桥梁，在科学和临床服务之间建立桥梁。我们计划进一步发展在转化和公共卫生模式框架内开展临床研究培训所需的基础设施。我们项目的一个关键前提是在神经科学、神经成像和遗传学之间建立联系，并将其应用于整个生命周期的精神和身体疾病的干预。我们还计划在我们已经建立的在对照临床试验中进行的治疗结果研究的传统和NIMH目前优先考虑的以增加公共卫生为导向的干预研究之间建立桥梁。我们的具体目标包括：(1)发展青年教师学者计划，为由我们的研究教育和培训中心（RETC）执行委员会竞争性选出的教师提供两年25%的工资支持。短期目标是促进这些教师发展k奖职业发展申请；长期目标是确保他们作为独立研究者在临床研究中取得成功；(2)开发双轨课程——一条用于转化研究，另一条用于干预研究。这两个课程将包括一学年的一个迷你课程（10节）和两个密集的夏季讲习班（每节一周）；(3)提供四项奖励，以资助青年学院学者进行试点研究，收集初步数据，以支持他们的k奖申请；(4)聘请一名专职统计员，为青年教师学者提供支持。讨论了有关招募代表性不足的少数民族和妇女的问题，并描述了评估该计划成功的具体标准（例如，增加资助的早期职业发展奖和职业中期以患者为导向的研究奖）。

This R25 application is organized around two overall themes-building bridges between basic and clinical research and building bridges between science and clinical service. We plan to develop further the infrastructure needed to conduct clinical research training within the frameworks of both translational and public health models. A key premise of our program is the importance of forging links between neuroscience, neuroimaging, and genetics and their applications to interventions with psychiatric and physical illnesses throughout the lifespan. We also plan to build bridges between the tradition we have established of treatment outcome research done in controlled clinical trials and the current priority accorded by NIMH to intervention research with an increased public health orientation. Our specific aims include: (1) development of a Junior Faculty Scholars Program that will provide 25 percent salary support for two years to faculty members selected competitively by the Executive Committee of our Research Education and Training Center (RETC). The short-term goal is to facilitate the development of K-award career development applications by these faculty; the long-term goal is to ensure their success as independent investigators doing clinical research; (2) development of a curriculum with two tracks-one for translational research and a second for intervention research. Both tracks will involve one mini-course during the academic year (10 sessions) and two intensive summer workshops (one week each); (3) provision of four awards for pilot research studies by Junior Faculty Scholars collecting initial data in support of their K-award applications; and (4) hiring of one full-time statistician who will provide support to the Junior Faculty Scholars. Issues regarding recruitment of underrepresented minorities and women are addressed, and specific criteria for evaluating the success of the program (e.g., an increase in funded early career development awards and mid-career patient-oriented research awards) are also described.