Multichannel Deep Brain Stimulation System

描述(由申请人提供)：本提案是根据RFA-NS-02-004(安全有效的脑深部刺激技术开发)提交的。我们已经解决了研究目标#3，“开发可充电的和/或具有更大范围的刺激率、刺激电流、脉冲宽度和脉冲波形的刺激器，并允许从电极记录以及刺激。” 1)我们将开发一种可充电的脑深部刺激刺激器，其刺激率、刺激电流和脉冲宽度比任何其他可用的系统都要宽。这项开发将包括外部充电器和编程刺激器所需的工具。 2)我们将开发一种用于脑深部刺激的刺激器，具有上述功能，可以安装在头骨上，从而消除通过颈部挖掘导线的需要。。这样可以在不需要全身麻醉的情况下植入DBS系统，并通过避免导线通过高流动性的颈部区域来降低导线骨折或断裂的风险。 3)我们将开发一种用于脑深部刺激的刺激器，其中包括感测神经元的电活动。该系统可以使用刺激电极进行感测，或者可以结合与刺激电极阵列集成的分开的记录电极。该系统还可以配置有用于单独的记录导线的连接器，该独立的记录导线可以放置在大脑中相对远离刺激区域的部分。 4)我们计划将上述刺激器提供给NIH深度脑刺激(DBS)联盟的成员以及其他DBS研究人员用于研究和测试。

DESCRIPTION (provided by applicant): This proposal is submitted in response to RFA-NS-02-004 (Technology development for safe and effective deep brain stimulation). We have addressed Research Objective #3, "The development of stimulators that are rechargeable and/or that have a wider range of stimulation rates, stimulation currents, pulse widths, pulse waveforms, and that permit recording from electrodes as well as stimulation." 1) We will develop a stimulator for deep brain stimulation that is rechargeable and that has a wider range of stimulation rates, stimulation currents, and pulse widths than any other available system. This development will include the external recharger and the tools required to program the stimulator. 2) We will develop a stimulator for deep brain stimulation with the above capabilities that can be mounted in the skull, thereby obviating the need to tunnel a lead through the neck. . This allows implantation of the DBS system without the need and the attendant risks of general anesthesia, and this reduces the risk of lead fracture or breakage by avoiding passage of the lead through the highly mobile neck area. 3) We will develop a stimulator for deep brain stimulation that includes sensing of the electrical activity of neurons. This system may use the stimulation electrodes for sensing or may incorporate separate recording electrodes integrated with the stimulation electrode array. The system may also be configured with a connector for a separate recording lead that may be place in a part of the brain that is relatively far removed from the area of stimulation. 4) We plan to make the above stimulators available to members of the NIH Deep Brain Stimulation (DBS) consortium as well as other DBS researchers for research and testing.