Equipment for Application of Microarray Technology

描述（由申请人提供）：德克萨斯大学圣安东尼奥分校的MBRS RISE项目申请资金，用于购买设备，以促进微阵列基因技术在研究和研究培训项目中的使用。目标是加强UTSA MBRS和MARC项目的研究和研究培训基础设施。微阵列基因技术正在彻底改变研究人员收集、查看和解释细胞中基因表达、基因拷贝数和多态性以及蛋白质水平数据的方式。此外，微阵列技术为人类健康的关键领域提供了前所未有的途径，包括疾病诊断和预后、治疗和药物发现。具体目标是：(1)获得将微阵列技术应用于正在进行和未来的生物医学研究项目所需的多用户设备和软件；(2)通过提供高通量生产和分析DNA微阵列的设备，加强MBRS和MARC师生的研究基础设施；(3)通过整合微阵列基因技术和与DNA相关的微阵列分析计算方法，提高mbr - rise和MARC U'STAR项目的研究培训和教育能力；(4)培养学生和教师掌握微阵列基因技术和与DNA微阵列基因分析相关的计算方法；(5)制定有效的评估计划，评估微阵列基因技术设备对MBRS和MARC师生的研究能力、生产力和竞争力的整体影响。12名教师和他们的MBRS和MARC学生建议在他们的研究和研究培训项目中立即使用该设备。

DESCRIPTION (provided by applicant): The MBRS RISE Program at the University of Texas at San Antonio requests funds to acquire equipment to facilitate the use of micro-array gene technology in research and research training projects. The goal is to enhance the research and research-training infrastructure of MBRS and MARC Programs at UTSA. Micro-array gene technology is revolutionizing the way in which researchers collect, view, and interpret data on gene expression, gene copy number and polymorphisms, and protein levels in cells. Moreover, micro-array technology is providing unprecedented access to key areas of human health including disease diagnosis and prognosis, treatment, and drug discovery. The specific aims are to: (1) acquire multi-user equipment and software necessary to apply micro-array technology to ongoing and future biomedical research projects; (2) enhance the research infrastructure of MBRS and MARC faculty and students by providing equipment for high through-put production and analysis of DNA microarrays; (3) enhance the research training and educational capabilities of the MBRS-RISE and MARC U'STAR programs by integrating micro-array gene technology and computational methods relating DNA to micro-array analysis; (4) train students and faculty in micro-array gene technology and computational approaches relating to DNA micro-array gene analysis; and (5) develop an effective evaluation plan to assess the overall impact of the micro-array gene technology equipment on research capability, productivity, and competitiveness of MBRS and MARC faculty and students. Twelve faculty members and their MBRS and MARC students propose to make immediate use of the equipment in their research and research training projects.