The Development of New Chemical-Tools to Study Chemokines Properties and Functions

趋化因子是在包括癌症在内的一系列人类疾病中在细胞迁移（趋化性）中起关键作用的蛋白质。该项目将专注于特定修饰趋化因子（例如硝化，硫酸化，氟化）的化学合成，目的是提供独特的化学生物学工具，可用于更好地了解这一重要蛋白质家族的生物学。这项工作的关键将是开发一种新的组合连接方法，该方法将用于以快速有效的方式生成趋化因子文库。这项工作还将寻求开发第一个针对PROTAC的CCL2。

Chemokines are proteins that play a critical role in cell migration (chemotaxis) in a range of human diseases including cancer. This project will focus on the chemical synthesis of specifically modified chemokines (e.g. nitrated, sulfated, fluorinated) with the aim of providing unique chemical-biology tools that can be used to develop a greater understanding of the biology of this important family of proteins. Key to this work will be the development of a novel combinatorial ligation approach which will be used to generate chemokine libraries in a rapid and efficient manner. The work will also look to develop the first CCL2 targeting PROTAC.