MECHANISMS & PERFORMANCE OF TRACEABLE UHMWPE IMPLANTS

描述(申请人提供)：超高分子量降解 聚乙烯(以下简称聚乙烯)伽马后接缝更换组件 空气中的辐射仍然被认为是一个重要的临床问题。 限制全关节成形术的寿命，这代表着 晚期退行性关节疾病患者的标准护理。 聚乙烯的氧化降解与加速有关 全关节置换组件的磨损、脆性断裂和分层。 尽管现在人们认识到，聚乙烯的降解对 在骨科部件损伤机制中的重要作用，至今仍在 不清楚与聚乙烯的机械降解有关的程度 对全髋关节置换术整体临床表现的影响，部分原因是 追踪灭菌和货架老化历史的后勤困难 组件，也由于实验的困难直接 测量取回的植入物的机械性能。的范围 与可追踪的、临床可检索的骨科相关的机械行为 组件是指导改进的开发的关键 聚乙烯，例如最近具有高度交联性的聚乙烯 已被引入全髋关节置换术的临床实践。目的 这项拟议的研究的目的是检查机械退化的影响 金属背衬髋臼假体植入后的临床表现 用于全髋关节置换的部件。

DESCRIPTION (provided by applicant): Degradation of ultra high molecular weight polyethylene (hereafter, polyethylene) joint replacement components after gamma irradiation in air continues to be recognized as a significant clinical problem limiting the longevity of total joint arthroplasties, which represent the standard of care for patients with advanced degenerative joint disease. Oxidative degradation of polyethylene has been associated with accelerated wear, brittle fracture, and delamination of total joint replacement components. Although it is now recognized that the degradation of polyethylene plays an important role in the damage mechanisms of orthopaedic components, it is still unclear the extent to which the mechanical degradation of polyethylene relates to the overall clinical performance of total hip arthroplasty, due in part to the logistical difficulty in tracing the sterilization and shelf aging history of the components, and also due to the experimental difficulty in directly measuring the mechanical behavior of retrieved implants. The range of mechanical behavior associated with traceable, clinically retrieved orthopedic components is critically needed to guide the development of improved polyethylenes, such as the highly crosslinked polyethylenes which have recently been introduced into clinical practice for total hip arthroplasty. The purpose of this proposed research is to examine the influence of mechanical degradation after implantation on the clinical performance of metal-backed acetabular components for total hip arthroplasty.