ROLES OF HOX GENES IN SKIN & HAIR FOLLICLE DEVELOPMENT

描述：（改编自申请人摘要）-独特的表达 遗传学上保守的同源异型盒（“HOX”）的许多成员的模式 在发育和成人皮肤中的基因家族都涉及这组 控制基因在图案和再生过程的皮肤。的 首席研究员有初步数据表明， 在出生前和出生后皮肤中过表达Hoxc 13（GC 13小鼠）表现出 滤泡和表皮角质形成细胞过度增殖。这些小鼠 表现出脱发和类似鱼鳞病的进行性皮肤缺损。这 动物模型将被用来定义这些潜在的分子机制 异常，通过研究Hoxc 13及其邻居Hoxc 13的表达， 筛选正常人皮肤中差异表达的mRNA， Hoxc 13突变小鼠皮肤，Hox 12敲除与显性的比较 功能获得性小鼠，以及Hoxc 13和Hoxc 12的转录调控。

DESCRIPTION: (Adapted from applicant's abstract) - The distinct expression patterns of many members of the phylogenetically conserved homeobox ("HOX") gene family in both developing and adult skin implicate this group of controller genes in patterning and regenerative processes of the skin. The principal investigator has preliminary data that transgenic mice over-expressing Hoxc13 (GC13 mice) in pre- and postnatal skin exhibit hyperproliferation of follicular and epidermal keratinocytes. These mice exhibit alopecia and a progressive skin defect resembling ichthyosis. This animal model will be used to define the molecular mechanisms underlying these abnormalities, by studying expression of Hoxc13 and its neighbor Hoxc13, screening for differentially expressed mRNAs in skin of normal versus Hoxc13-mutant mouse skin, comparison of Hox12 knockout versus dominant gain-of-function mice, and transcriptional regulation of Hoxc13 and Hoxc12.