Maternal antidepressant use and fetal neurobehavior

描述（由申请人提供）：拟议研究的总体目标 职业发展计划是准备调查员，艾米索尔兹伯里博士， 作为胎儿行为领域独立调查员的职业生涯 发展和产妇心理健康。调查人员在这些领域的工作重点 代表了强烈的愿望，了解机制和调解人， 儿童精神疾病的发展。作为实现 长期目标，索尔兹伯里博士将研究胎儿和新生儿的神经行为， 患有重度抑郁症（MDD）的女性，通过结构化访谈诊断， 有和没有抗抑郁药（S SRI）暴露。本研究将在 在高危胎儿和新生儿的方法学方面进行了强化培训（Dr. 巴里莱斯特），胎儿监测技术（珍妮特DiPietro博士），结构化 访谈技术（SCID，SADS）和正在进行的教学培训和临床 与情绪障碍和药物领域的顶级专家进行监督 妇女管理（凯瑟琳维斯纳博士和泰瑞·皮里斯坦博士），以及 母胎医学（斯蒂芬卡尔博士）。莱斯特博士将担任 本计划的主要导师和整个奖励过程中的资源提供者 期其他技能将通过研究课程获得 布朗大学的设计和回归分析以及先进的 产科超声波培训拟议的职业发展计划将 建立在索尔兹伯里博士在胎儿和 新生儿行为调查员得到了布朗医疗中心的全力支持 学校，妇女和婴儿医院，和她的赞助商，以实现目标 在这个职业发展计划中。广泛的长期目标 研究计划是确定SSRI是否有不同的效果 暴露和MDD对胎儿和新生儿神经行为发育的影响。数据 将提供有关胎儿中枢神经系统如何对两个母体 生物环境，并有助于迫切需要的 怀孕期间情绪障碍的治疗指南的信息。的 建议研究计划的具体目标是：以确定影响 母体SSRI治疗的MDD（正常胸腺）与非SSRI暴露的活性MDD， 胎儿神经行为和控制，2。为了确定母体S SRI治疗的MDD与非SSRI暴露的活性MDD对新生儿神经行为和 对照本研究的第二个目的是检查 从胎儿到新生儿神经行为测量的个体差异 期

DESCRIPTION (provided by applicant): The overall goal of the proposed research career development program is to prepare the investigator, Dr. Amy Salisbury, for a career as an independent investigator in the areas of fetal behavioral development and maternal mental health. The investigator's focus in these areas represents a strong aspiration to understand the mechanisms and mediators in the development of childhood mental illness. As a first step in achieving the long-term goals, Dr. Salisbury will study fetal and newborn neurobehavior in women with Major Depressive Disorder (MDD), diagnosed by structured interview, with and without antidepressant (S SRI) exposure. This study will be executed with intensive training in methodologies with at-risk fetuses and newborns (Dr. Barry Lester), fetal monitoring techniques (Dr. Janet DiPietro), structured interview techniques (SCID, SADS) and ongoing didactic training and clinical supervision with top experts in the field of mood disorders and medication management in women (Dr. Katherine Wisner and Dr. Teri Pearistein), and maternal-fetal medicine (Dr. Stephen Carr). Dr. Lester will serve as the primary mentor of this program and resource provider throughout the award period. Additional skills will be attained through coursework on research design and regression analyses at Brown University as well as advanced obstetric ultrasound training. The proposed program of career development will build on Dr. Salisbury's established research and clinical skills in fetal and newborn behavior. The investigator has the full support of the Brown Medical School, Women & Infants' Hospital, and her sponsors to achieve the goals outlined in this career development program. The broad, long-term objective of the research plan is to determine if there are differential effects of SSRI exposure and MDD on fetal and newborn neurobehavioral development. The data will provide information about how the fetal CNS responds to the two maternal biological environments as well as contribute to the urgently needed information for treatment guidelines of mood disorders during pregnancy. The specific aims of the proposed research plan are 1. To determine the effect of maternal S SRI-treated MDD (euthymic) versus nonSSRI exposed active MDD on fetal neurobehavior and controls, 2. To determine the effect of maternal S SRI-treated MDD versus non-SSRI exposed active MDD on newborn neurobehavior and controls. A secondary aim of this study is to examine the stability of the individual differences of neurobehavioral measures from the fetal to newborn period.