Chiral lewis Base-Catalyzed Asymmetric Reactions

描述：(申请人的描述)这项研究的长期目标 方案是开发高效、可靠、实用的不对称催化材料 反应，这将为学术界和工业界的合成化学家提供 具有必要的工具来设计高效、实用和环保的 药物和其他生物合成的友好路线 活性化合物。我们努力通过发现和实现这一目标 易得手性催化剂的开发及手性催化剂的广泛探索 它们促进催化不对称反应的能力。具体来说，我们将 重点开发易得的手性路易斯碱催化剂 通过一种方法实现广泛的不对称亲核-亲核反应 它结合了广泛的反应筛选，密集的开发和 反应条件优化，机理和结构考虑周到 学习。为了说明这些不对称反应在 生物医学研究，我们概述了利用这些不对称的合成路线 将易得的前手性前体转化为各种手性前体的反应 光学活性手性构筑块用于不对称合成 具有生物学意义的化合物。

DESCRIPTION: (Applicant's Description) The long-term goal of this research program is to develop efficient, reliable and practical catalytic asymmetric reactions, which will provide synthetic chemists in both academia and industry with the necessary tools to design efficient, practical and environmentally friendly routes for the synthesis of pharmaceuticals and other biologically active compounds. We strive to achieve this goal through the discovery and development of readily accessible chiral catalysts and a broad exploration of their ability to promote catalytic asymmetric reactions. Specifically we will focus on the development of readily available chiral Lewis base catalysts for a wide range of asymmetric nucleophile-electrophile reactions via an approach that combines extensive reaction screening, intensive development and optimization of reaction conditions, and thoughtful mechanistic and structural studies. To illustratethe potential usefulness of these asymmetric reactions in biomedical research, we outline synthetic routes which utilize these asymmetric reactions to transform readily available prochiral precursors into various optically active chiral building blocks for asymmetric synthesis of biologically interesting compounds.