NATURALLY OCCURRING POLYENES VIA ORGANOMETALLICS

由多个烯属位点组成的天然存在的化合物在生理活性剂中占据特殊的位置。多烯类抗生素包括（1）多烯大环内酯类抗生素，临床上有抗真菌价值。形成离子通道的材料通常含有四到七个共轭排列的E-烯烃。使用连接试剂快速制备氧代四到七烯子节的立体化学均匀的形式是追求;（2）新的路线，轴承轴手性联芳基，特别是联芳基部分的万古霉素和米歇尔胺B，将进行研究。前者是世界上抵御某些细菌感染的最后防线之一，后者是一种特别有效的抗艾滋病化合物。这两个目标将通过有机金属中间体衍生自分子内联芳基偶联策略。立体诱导将由连接各个芳基组分的系链的性质控制。因此，本申请不仅讨论了在当前资助期间取得的相当大的已发表进展，而且还讨论了大量未发表的数据，以支持本文概述的我们多烯计划的持续和特别是新方向。在胺中，和（B）镍-炭作为有效的、廉价的和环境友好的催化剂，用于实现C-C带的形成，这将帮助我们达到我们的目标，并为合成界提供一般用途。

Naturally occurring compounds consisting of multiple olefinic sites occupy a special niche among physiologically active agents. Included in this polyene group are (1) the polyene macrolide antibiotics, clinically valued as anti-fungals. The ion channel-forming materials usually contain between four and seven E-olefins in a conjugated array. The use of conjunctive reagents for rapidly preparing oxo tetra- to heptaene subsections in stereochemically homogeneous form is to be pursued; (2) new routes to biaryls bearing axial chirality, in particular the biaryl portions of vancomycin and michellamine B, will be studied. The former is one of the world's last lines of defense against certain bacterial infections, and the latter is an especially effective anti-AIDS compound. Both targets will derive from an intra-molecular biaryl coupling strategy via organometallic intermediates. Stereoinduction will be controlled by the nature of the tether joining the individual aryl components. Thus, this application discusses not only considerable published progress made during the currant grant period, but extensive unpublished data in support of both the continuing and especially, the new directions in our polyene program, outlined herein. In amines, and (b) nickel-on-charcoal as an effective, inexpensive and environmentally benign catalyst for effecting C-C band formations which should assist us in reaching our goals, and provide general utility as well to the synthetic community.