New Technologies for Catalysis in Water

已经鉴定了形成纳米胶束的两亲物“PTS”，其允许几种Pd-和 Ru催化的交叉偶联在作为唯一溶剂的水中发生，并且在室温下进行。 温度，在高分离收率。新工艺包括Heck、Suzuki、Sonogashira和 烯烃交叉复分解反应，其中产物分离特别容易。若干附加 计划基于“胶束效应”进行研究。“设计师”表面活性剂的概念 到有机金属催化是先进的，在这个建议，并代表了一个变量基本上 被合成人社区忽视了这项技术也将应用于其他 重要的交叉耦合，如胺化和氢化物对迈克尔的不对称加成 受体，都在室温下的水中。

A nanomicelle-forming amphiphile "PTS" has been identified that allows for several Pd- and Ru-catalyzed cross-couplings to take place in water as the only solvent, and at room temperature, in high isolated yields. The new processes include Heck, Suzuki, Sonogashira, and olefin cross-metathesis reactions, where product isolation is especially facile. Several additional studies are planned based on the "micellar effect." The notion of "designer" surfactants applied to organometallic catalysis is advanced in this proposal, and represents a variable essentially overlooked by the synthetic community. This technology also is to be applied to other important cross-couplings, such as aminations and asymmetric additions of hydride to Michael acceptors, all in water at room temperature.