Molecular and Cellular Mechanisms of Host Defense

描述（由申请人提供）：该培训计划旨在为年轻科学家在免疫学研究中的独立职业做好准备。在这一领域需要聪明的，受过全面训练的调查人员是巨大的：自身免疫性疾病，先天性和获得性免疫缺陷，淋巴肿瘤是当今最重要和最令人困惑的发病原因之一。在宿主防御的细胞和分子机制水平上的研究对于阐明和预防骨髓和实体器官移植的免疫并发症以及对基因治疗的免疫应答也至关重要。实习生（博士前和博士后（M.D.或博士学位）研究员）由16个项目教师（医学博士，医学博士/哲学博士、或博士学位）在贝勒医学院免疫学系担任主要或联合职务，其研究项目涉及现代免疫学的各个领域，包括淋巴细胞分化、抗原受体基因重排和表达、肽-MHC相互作用、淋巴细胞活化和凋亡、对HIV的免疫反应、基因治疗、造血干细胞生物学、白细胞运输和效应器功能中的粘附分子以及细胞因子。支持三名博士前和三名博士后学员（包括一名医学博士）的人）要求。博士前培训生主要从已被录取进入免疫学研究生课程的学生中选择，并选择一名培训教师作为他们的论文导师。通过其他课程进入参与教师实验室的学生也可以考虑。这些受训人员完成免疫学基础和高级领域以及现代细胞和分子生物学的核心课程。博士后培训生从高素质的博士生中选拔。或者医学博士申请人个人培训学院。除了研究培训和职业发展的教师指导外，博士后学员还可以参加高级免疫学课程。

DESCRIPTION (provided by applicant): This training program is designed to prepare young scientists for independent careers in immunological research. The need for bright, thoroughly trained investigators in this area is great: diseases of autoimmunity, congenital and acquired immunodeficiency, and lymphoid neoplasms are among the most significant and perplexing causes of morbidity today. Research at the level of cellular and molecular mechanisms of host defense is also critical for elucidating and preventing the immunologic complications of bone marrow and solid organ transplantation and immune responses to gene therapy. Trainees (predoctoral and postdoctoral (M.D. or Ph.D.) fellows) are mentored by one of 16 program faculty (M.D., M.D./Ph.D., or Ph.D.) with primary or joint appointments in the Department of Immunology at Baylor College of Medicine, whose research programs address diverse areas of modern immunology, including lymphocyte differentiation, antigen receptor gene rearrangement and expression, peptide-MHC interaction, lymphocyte activation and apoptosis, immune responses to HIV, gene therapy, hematopoeitic stem cell biology, adhesion molecules in leukocyte trafficking and effector function, and cyotokines. Support for three predoctoral and three postdoctoral trainees (including an M.D. fellow) is requested. Predoctoral trainees are selected primarily from among students who have matriculated into the immunology graduate program and chosen one of the training faculty as their thesis mentor. Students who have entered the laboratories of participating faculty through other programs may also be considered. These trainees complete a core curriculum in basic and advanced areas of immunology and in modern cell and molecular biology. Postdoctoral trainees are selected from highly qualified Ph.D. or M.D. applicants to individual training faculty. In addition to faculty guidance of research training and career development, postdoctoral trainees may take advanced immunology courses.