Postdoctoral Training in the Biology of Drug Abuse

描述：(申请人提供)： 这是一份竞争续签博士后培训补助金的提案。 位于密歇根大学的多学科环境中。这13个 教职员工都是NIDA资助者(或合作伙伴)，并在 药物滥用的神经生物学，特别强调阿片类药物领域 还有精神刺激剂。该提案的重点是博士培养。 和医学博士后研究员在国家最先进的研究方法 精神活性药物滥用的潜在机制。这包括研究 导致易感性的遗传、发育和环境因素 物质滥用：药物滥用的作用模式在分子上， 细胞、解剖学和行为水平；以及 通过神经机制调节的脑部活性药物 可塑性。其工作假设是大脑的功能和结构 与慢性药物使用相关的重构建立在耐受性的基础上， 对这些药物的敏感化、身体依赖和心理上瘾。 密歇根大学的药物滥用研究社区是 高品质，在该领域有着悠久的历史。除了他们的个人优势之外， 培训的教职员工都有长期的科学培训。 彼此之间的关系。这些历史上的优势最近被 通过多项新举措显著增强了该大学的实力 密歇根州，旨在促进一般的生命科学研究，以及 尤其是神经科学研究。它们包括最先进的工具，用于 小鼠和大鼠遗传学、基因组学、蛋白质组学和信息学。因此，我们的 受训者将受益于高度复杂但极具支持性的 研究和培训环境。

DESCRIPTION: (Provided by Applicant): This is a proposal for a competing renewal of a postdoctoral training grant located in a multidisciplinary setting at the University of Michigan. The 13 faculty are all NIDA grantees (or Co-Pls) and have expertise in the neurobiology of substance abuse, with particular emphasis on the area of opioid and psychostimulant drugs. The focus of the proposal is the training of Ph.D. and M.D. postdoctoral fellows in state-of-the-art approaches for studying mechanisms underlying abuse of psychoactive drugs. This includes studying the genetic, developmental and environmental factors that lead to vulnerability to substance abuse: the mode of action of drugs of abuse at the molecular, cellular, anatomical and behavioral levels; and the long-term consequences of pschoactive drugs on the brain, as mediated through mechanisms of neural plasticity. The working assumption is that the functional and structural brain remodeling associated with chronic drug use lies at the basis of tolerance, sensitization, physical dependence, and psychological addiction to these drugs. The drug abuse research community at the University of Michigan is of high quality and has a long history in the field. Beyond their individual strengths, the training faculty members have long-term scientific and training relationships with each other. These historical strengths have recently been significantly enhanced with a number of new initiatives' at the University of Michigan, designed to facilitate life sciences research in general, and neuroscience research in particular. They include state-of-the-art tools for mouse and rat genetics, genomics, proteomics, and informatics. Thus, our trainees will profit from a highly sophisticated, yet extremely supportive, research and training environment.