Meconium markers of fetal neurotoxicant exposures

描述(由申请人提供) 环境毒物已经牵涉到许多发展中的 精神错乱。不幸的是，这些暴露对健康的影响 发生在实际接触之后很久。对于胎儿来说，暴露在空气中的估计是 由于难以获得用于分析的组织，因此尤其困难。 低至中等暴露于环境毒物的生物标志物，如 以及这些有害神经发育影响的生物标记物 暴露将使受影响的人能够更早地识别和干预 婴儿，认识到处于接触风险中的妇女，并促进关于 环境暴露于混合毒物之间的剂量-反应关系 毒物和其他已知的发育神经毒物(乙醇和 尼古丁)和神经发育结果。胎粪，第一个经过的粪便 一名新生儿，已被用来确定是否有滥用药物的机会。这个 已有报告称胎粪中存在环境毒物。研究 在调查人员的实验室中已经显示出在 胎粪和粪便中脂肪酸乙酯(乙醇代谢产物)的含量 两位母亲自我报告的饮酒水平都是低到中等 妊娠与婴儿在贝利婴儿量表上的表现 6个月、12个月和24个月时发育。这项提案旨在解决 假设环境毒物以及尼古丁和乙醇 胎粪中的代谢物是暴露于 发育性神经毒物，可能表明婴儿有贫困的风险 神经发展，通过实现以下两个具体目标：1)确定 一年中准确分析比较6类神经毒物的方法学 胎粪的单一样本。2)描述这些神经毒物的存在 在400名婴儿的队列中(项目1)，并描述他们与 更多传统的孕产妇和环境措施，作为 项目1.项目1的目标是确定胎粪措施的特点 神经发育结果。这些研究将利用患者队列和 项目1“胎粪”中所述的孕产妇/婴儿/环境措施 来自已知的禁酒者和我们婴儿托儿所的随机胎粪。这些 研究将提供关于以下项目的可行性和实用性的初步数据 胎粪分析评估环境神经毒物对人体健康的影响 人类胎儿。

DESCRIPTION (provided by applicant) Environmental toxicants have been implicated in a number of developmental disorders. Unfortunately, the health effects subscribed to these exposures occurs long after the actual exposure. For fetuses, exposure estimates are particularly difficult due to the difficulty of obtaining tissue for analysis. Biological markers for low to moderate exposure to environmental toxicants, as well as biological markers for adverse neurodevelopmental effects of these exposures would allow earlier identification and intervention for affected infants, recognition of women at risk for exposure, and facilitate research on dose-response relationships between environmental exposures to mixtures of toxicants and to other known developmental neurotoxicants (ethanol and nicotine) and neurodevelopmental outcome. Meconium, the first stool passed by a newborn, has been used to establish exposure to drugs of abuse. The presence of environmental toxicants in meconium has been reported. Research in the investigators laboratory has shown a significant associations between the quantity of fatty acid ethyl esters (ethanol metabolites) in meconium and both maternal self-reported low to moderate levels of drinking during pregnancy and the infants performance on the Bayley Scales of Infant Development at 6, 12, and 24 months of age. This proposal seeks to address the hypothesis that environmental toxicants as well as nicotine and ethanol metabolites in meconium are useful biological markers for exposure to developmental neurotoxicants, and may indicate infants at risk for poor neurodevelopment, by achieving the following 2 specific aims: 1) Determine a methodology to accurately analyze and compare 6 classes of neurotoxicants in a single sample of meconium. 2) Describe the presence of these neurotoxicants in a cohort of 400 infants (Project 1) and characterize their relationship to more traditional maternal and environmental measures obtained as part of Project 1. Project 1 will aim to characterize the meconium measures with neurodevelopmental outcome. These studies will utilize the patient cohort and maternal/infant/environmental measures as described in Project 1, meconium from known teetotalers and random meconium from our well baby nursery. These studies will provide preliminary data on the feasibility and utility of meconium analysis to gauge the influence of environmental neurotoxicants on human fetuses.