HIGH-RESOLUTION MAGNETIC SECTOR MASS SPECTROMETER

该提案是对印第安纳州大学化学系质谱设施的仪器升级的请求。升级将包括购买一台高分辨率磁扇形质谱仪，该质谱仪具有电子碰撞、化学电离、液体二次离子质谱、场解吸和电喷雾电离能力，以支持合成化学（有机、无机和生物化学）领域的研究。目前，质谱设施配备了一个20岁的Kratos MS 80与EI，CI和快原子轰击（FAB）。MS80由于其旧的设计（低加速电压和缺乏后加速离子检测系统）而无法分析中等至大尺寸的分子。 由于电离方法的局限性，许多化合物如多电荷配合物和多电荷生物分子不能被分析。事实上，我们系的几个无机化学和生物化学研究小组不得不将这些类型的样品送到校外以获取ESI数据。最重要的是，我们MS80的老化组件开始出现常规故障。奎托斯不再为它的部门工具制造或提供足够的支持。因此，修理仪器需要更长的时间，长时间的仪器停机时间经常中断我们部门的研究。获得一个现代化的仪器，以提供更好的质谱支持将是一个实质性的增强领域的合成在印第安纳州。这次升级将极大地提高我们表征分子样品的能力，并有望提高化学系和I.U.其他学校的研究能力。系统获得拟议系统的时机至关重要。

This proposal is a request for an instrument upgrade in the Mass Spectrometry Facility at Indiana University in the Department of Chemistry. The upgrade will consist of the purchase of a high-resolution magnetic sector mass spectrometer with electron impact (EI), chemical ionization (CI), liquid secondary ion mass spectrometry (LSIMS), field desorption (FD) and electrospray ionization (ESI) capabilities to support research in the area of synthetic chemistry (organic, inorganic and biochemistry). Currently the mass spectrometry facility is equipped with a single 20-year old Kratos MS80 with EI, CI and fast atom bombardment (FAB). The MS80 is incapable of analyzing medium to large sized molecules because of its old design (low accelerating voltage and lack of post acceleration ion detection system). Because of the limited ionization methods, many compounds such as multiply charged coordination complexes and multiply charged biomolecules cannot be analyzed. In fact, several research groups in inorganic chemistry and biochemistry in our department have to send these types of samples off- campus for ESI data. Most importantly, the aging components of our MS80 are beginning to fail routinely. Kratos no longer makes or provides adequate support for its sector instruments. As a result, repairing the instrument takes longer time and the prolonged instrument downtimes have frequently interrupted the research in our department. Acquiring a modern instrument to provide better mass spectrometric support will be a substantial enhancement in areas of synthesis in Indiana. This upgrade will provide tremendous improvements in our ability to characterize molecular samples and is expected to enhance research capabilities in the department of Chemistry and at other schools across the I.U. system. The timing of acquiring the proposed system is critical.