Small Animal Echocardiography System

描述（由申请人提供）：评价心脏功能的能力 在过去的五年里，在小动物模型中取得了显着进展。 小鼠超声心动图不再是新奇事物，现在被广泛使用， 接纳的话适应日益复杂的高分辨率成像 最初为人类开发的系统现在可以对成人和成年人进行成像。 （质量约30克）和新生小鼠（质量约1克）。此外，本发明还提供了一种方法， 鸡胚（E10 -15）心脏和大血管成像的经验是 快速获得。这些技术需要几个人的合作投入 包括主要研究者在内的个人，其产生了动物 模型进行测试，并由经验丰富的超声医师获得，记录， 解释图像数据。在小鼠超声心动图中，M模式和冠状动脉内 使用探针评估腔室尺寸、壁缩短分数， 射血分数利用多普勒功能，还可以评估流速。 此外，还可以采用经食管成像来提供高质量的图像。 大血管的分辨率成像。在10 - 15天的鸡胚中， 此外，还可以评估心输出量。这些研究 需要专用探头、成像系统和专用离线 图像分析设备。此外，他们需要熟练和敬业的 具有丰富超声心动图经验的超声医师的协助， 数据的采集、分析和解释。在本申请中，我们 申请资金购买Acuson Sequoia C256超声心动图 小型实验动物心脏功能分析系统。在 威尔-康奈尔大学至少有七名研究人员预计将使用这种仪器 每年进行1500至2200项ECHO研究。该项目有 Weil-Cornell动物资源研究中心此外该 该机构已承诺为技术助理提供工资支持 和服务合同资金，直到工具成为 自给自足

DESCRIPTION (provided by applicant): The ability to evaluate cardiac function in small animal models has progressed significantly within the last five years. No longer a novelty, mouse echocardiography is now widely utilized and accepted. The adaptation of increasingly sophisticated high resolution imaging systems developed originally for humans now enables imaging of both adult (about 30 grams in mass) and neonatal mice (about 1 gram in mass). In addition, experience in imaging the heart and great vessels of chick embryos (El0-15) is gaining rapidly. These techniques require the collaborative input of several individuals including a primary investigator, who has generated the animal model to be tested, and an experienced sonographer to obtain, record, and interpret the image data. In mouse echocardiography, M-mode and intracoronary probes are employed to assess chamber size, fractional wall shortening, and ejection fraction. With Doppler capability, one can also assess flow rates. Transesophageal imaging, furthermore, can also be employed to provide high resolution imaging of the great vessels. In the day 10 to 15 chick embryo, furthermore, assessments of cardiac output can also be made. These studies require dedicated probes, access to imaging systems, and dedicated off-line image analysis equipment. In addition, they require skilled and dedicated assistance of a sonographer with extensive echocardiographic experience for acquisition, analysis, and interpretation of the data. In this application, we request funds for the purchase of an Acuson Sequoia C256 echocardiography system for the analysis of cardiac function in small experimental animals. At least seven investigators at Weil-Cornell anticipate employing this apparatus to conduct a total of 1500 to 2200 ECHO studies per year. The project has the approval of the Weil-Cornell Research Animal Resource Center. In addition, the institution has committed to providing salary support for a technical assistant and service contract funds until such time as the instrument becomes self-supporting.