Equipment Supplement to MBRS/SCORE Grant

描述（由申请人提供）：本申请的目的是通过提供三个重要的，最先进的设备和一名全职技术人员，扩大和加强加州州立理工大学波莫纳分校细胞和分子生物学的核心设施。这个核心设施为9个SCORE研究项目提供服务，该设施的改善将显著改善科研环境，为若干项目提供创新方法，并有助于SCORE研究项目的成功。通过使SCORE研究项目受益，核心设施的增强将有助于实现加州理工学院SCORE项目的长期目标：1)显著提高大学的研究能力，最终目标是增加被忽视的少数民族学生的数量，这些学生有动力追求生物医学科学家的职业；2)开展高质量的研究，解决与人类健康和疾病有关的基本生物和化学问题；3)改善大学的研究基础设施，帮助招募训练有素、雄心勃勃的新教师。三项设备为：1)冷冻断裂蚀刻仪一台，直接支持三个SCORE资助项目的专项目标；2)一台流式细胞仪，支持三个SCORE项目，并可能用于加州理工学院的其他两名教员；3)多图像管理系统，支持6个项目。设备技术员将直接支持8个项目。强有力的体制支持将采取承诺支付购货税（约30 980美元）和支付维修合同（每年约18 000美元）的形式。冷冻断裂装置将放置在我们1500平方英尺的电子显微镜中心，由一名技术人员协调使用。另外两个项目将位于我们1264平方英尺的细胞/分子生物学仪器核心设施，并由新的设备技术人员监督。该设施位于我们的研究设施的中间，可以从六个进行SCORE研究的实验室直接“24小时”访问。

DESCRIPTION (provided by applicant): The purpose of this application is to expand and enhance the core facility for cellular and molecular biology at California State Polytechnic University, Pomona by providing three important, state-of-the-art pieces of equipment and a full-time technician. This core facility serves nine SCORE research projects and enhancement of this facility will significantly enhance the scientific research environment, provide innovative approaches to several of the projects, and contribute to the success of the SCORE research projects. By benefiting the SCORE research projects, enhancement of the core facility will contribute to the long-term objectives of the SCORE Program at Cal Poly: 1) to significantly improve the research capabilities of the University with the ultimate objective of increasing the number of underrepresented minority students who are motivated to pursue careers as biomedical scientists; 2) to conduct high-quality research that addresses fundamental biological and chemical issues relevant to human health and disease; and 3) improve the research infrastructure at the university and help in the recruitment of well-trained, ambitious new faculty. The three items of equipment are: 1) a Freeze-Fracture-Etch Apparatus, directly supporting the Specific Aims of three funded SCORE projects; 2) an Analytic Flow Cytometer, supporting three SCORE projects and potentially of use to two other faculty members at Cal Poly; and, 3) a Multi-lmager System, supporting six projects. The equipment technician would directly support eight projects. Strong institutional support for the proposal will take the form of a commitment to pay the taxes on the purchases (ca. $30,980) and to pay for maintenance contracts (ca. $18,000/year). The freeze-fracture device will be located in our 1,500 square foot electron microscopy center and its use coordinated by a technician. The other two items will be located in our 1,264 square foot cell/molecular biology instrument core facility and supervised by the new equipment technician. This facility is located in the middle of our research facility with immediate, "24-7" access from six of the labs in which SCORE research is being conducted.